OBJECTIVES We sought to study atrial vulnerability in patients with Brugada syndrome. BACKGROUND Atrial fibrillation (AF) often occurs in patients with Brugada syndrome, but atrial vulnerability in Brugada syndrome has not been evaluated. METHODS The patient group consisted of 18 patients with Brugada syndrome. The control group consisted of 12 age- and gender-matched subjects who had neith...

Brugada syndrome is characterized by right bundle-branch block, ST elevation in leads V 1 through V 3 and normal QT interval. Ventricular fibrillation frequently occurs in patients with Brugada syndrome. There have been few reports of anesthetic management of Brugada patients. We managed a 47-year-old man with Brugada syndrome, who underwent hemilaminectomy under general anesthesia, without unt...

In 19 patients (14 females, mean age 49.1 ± 11.3 years) with typical arrhythmogenic cardiomyopathy and provocable type I Brugada ECG pattern by ajmaline administration were analysed by novel electrocardiographic features as having "true" or "false" Brugada syndrome. Three patients turned out as having false Brugada syndrome, the diagnosis is pure arrhythmogenic cardiomyopathy. In 16 patients, h...

Test code: CA0901 The Blueprint Genetics Brugada Syndrome Panel is an 11-gene test for genetic diagnostics of patients with clinical diagnosis of suspicion of Brugada syndrome. Brugada syndrome has autosomal dominant pattern of inheritance. Genetic diagnosis can confirm clinical diagnosis and patient’s arrhythmia mechanism. Test results can also guide risk assessment and treatment strategies. I...

BACKGROUND Brugada syndrome is an inherited cardiac condition transmitted with an autosomal dominant pattern which can lead to sudden cardiac death from malignant ventricular arrhythmias. The RANGRF gene has recently been proposed to be associated with Brugada syndrome. This gene encodes the MOG1 protein, a co-factor required for the full functioning of the cardiac sodium channel Nav1.5. The no...

______________________________________________ IV ACKNOWLEDGEMENTS ______________________________________ VI TABLE OF CONTENTS _______________________________________ VII LIST OF FIGURES _________________________________________ XIII LIST OF TABLES __________________________________________ XV LIST OF ABBREVIATIONS ____________________________________ XVI CHAPTER 1 GENERAL INTRODUCTION 1.1 Brug...

Test code: CA0901 The Blueprint Genetics Brugada Syndrome Panel is an 11-gene test for genetic diagnostics of patients with clinical diagnosis of suspicion of Brugada syndrome. Brugada syndrome has autosomal dominant pattern of inheritance. Genetic diagnosis can confirm clinical diagnosis and patient’s arrhythmia mechanism. Test results can also guide risk assessment and treatment strategies. I...

Test code: CA0901 The Blueprint Genetics Brugada Syndrome Panel is an 11-gene test for genetic diagnostics of patients with clinical diagnosis of suspicion of Brugada syndrome. Brugada syndrome has autosomal dominant pattern of inheritance. Genetic diagnosis can confirm clinical diagnosis and patient’s arrhythmia mechanism. Test results can also guide risk assessment and treatment strategies. I...

Brugada syndrome is an inherited cardiac condition with the potential for development of life-threatening arrhythmias in relatively young individuals without significant structural cardiac abnormalities. The condition is characterized by a distinct coved-type ST segment elevation in the right precordial leads (V1-V3). This hallmark pattern (type 1) is often dynamic and sometimes concealed, and ...