objective(s) in the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of rosa damascena on tracheal smooth muscle of guinea pigs were examined. materials and methods the relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0....

The incidence of asthma is increasing worldwide, but morbidity and mortality are decreasing because of improvements in medical care. Although the incidence of severe perioperative bronchospasm is relatively low in asthmatics undergoing anaesthesia, when it does occur it may be life-threatening. The keys to an uncomplicated perioperative course are assiduous attention to detail in preoperative a...

BACKGROUND The synthetic vasoactive intestinal peptide (VIP) analogue Ro 25-1553 is a selective VIP-PACAP type 2 (VPAC(2)) receptor agonist that causes a bronchodilatory effect in guinea pigs in vivo. The effect of Ro 25-1553 given by inhalation to patients with asthma was studied and compared with that of a long acting beta(2) adrenoceptor agonist. METHODS Twenty four patients with moderate ...

Recent studies have suggested that theophylline, a nonspecific phospho-diesterase inhibitor, has useful anti-inflammatory actions in asthma. Phosphodiesterase 4 (PDE4) represents the predominant PDE isoenzyme present in inflammatory cells. PDE4 inhibitors might, therefore, have beneficial effects in asthma. Side-effects, specifically nausea, have limited the use of existing agents. CDP840 is an...

In healthy individuals, airway resistance has an inverse relationship with lung volume.1 Moreover, deep inhalation is thought to maintain airway smooth muscle homeostasis and to possess bronchodilating and bronchoprotective properties against challenge agents.2-6 The bronchodilatory effect of deep inhalation is clearly impaired in asthma patients2,7,8; however, the bronchoprotective properties ...

Introduction: The World Health Organization has estimated that 15 million disability-adjusted life years (DALYs) are lost annually due to asthma, representing 1% of the total global disease burden. Racemic Salbutamol and Levo Salbutamol both have potent broncho-dilatory effect and therefore, both are used in the treatment of Asthma. The study was conducted to compare bronchodilatory efficacy po...

BACKGROUND We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. METHODS We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 +/- 2.2 yrs of age, mean +/- SE...

carum copticum is a grassy and annual plant which is believed to have several therapeutic effects, including anti-asthmatic properties. we have therefore studied the bronchodilatory and anticholinergic effects of 4 rnl aqueous extract (ae), 0.0 5 ml ethanol extract (ee), and 0.0 0 5 ml essential oil (eo) of carum copticum and 1 rnl of a 5 mm solution of its main ingredient, thymol (t), in compa...