BACKGROUND The synthetic vasoactive intestinal peptide (VIP) analogue Ro 25-1553 is a selective VIP-PACAP type 2 (VPAC(2)) receptor agonist that causes a bronchodilatory effect in guinea pigs in vivo. The effect of Ro 25-1553 given by inhalation to patients with asthma was studied and compared with that of a long acting beta(2) adrenoceptor agonist. METHODS Twenty four patients with moderate ...

Introduction: The World Health Organization has estimated that 15 million disability-adjusted life years (DALYs) are lost annually due to asthma, representing 1% of the total global disease burden. Racemic Salbutamol and Levo Salbutamol both have potent broncho-dilatory effect and therefore, both are used in the treatment of Asthma. The study was conducted to compare bronchodilatory efficacy po...

BACKGROUND We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. METHODS We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 +/- 2.2 yrs of age, mean +/- SE...

carum copticum is a grassy and annual plant which is believed to have several therapeutic effects, including anti-asthmatic properties. we have therefore studied the bronchodilatory and anticholinergic effects of 4 rnl aqueous extract (ae), 0.0 5 ml ethanol extract (ee), and 0.0 0 5 ml essential oil (eo) of carum copticum and 1 rnl of a 5 mm solution of its main ingredient, thymol (t), in compa...

Carum copticum is a grassy and annual plant which is believed to have several therapeutic effects, including anti-asthmatic properties. We have therefore studied the bronchodilatory and anticholinergic effects of 4 rnL aqueous extract (AE), 0.0 5 mL ethanol extract (EE), and 0.0 0 5 mL essential oil (EO) of Carum copticum and 1 rnL of a 5 mM solution of its main ingredient, thymol (T), in ...

BACKGROUND There are no published studies that have compared bronchodilatory effect of inhaled budesonide/formoterol combination with budesonide/salbutamol delivered by metered dose inhaler with a spacer in acute exacerbation of asthma in children. We, therefore, compared the bronchodilatory effects of inhaled budesonide/formoterol (dose: 200 μg and 12 μg respectively) combination with budesoni...

Zileuton, a 5-lipoxygenase (5LO) inhibitor, displays complex pharmaokinetic (PK)-pharmacodynamic (PD) behavior. Available clinical data indicate a lack of dose-bronchodilatory response during initial treatment, with a dose response developing after ~1-2 weeks. We developed a quantitative systems pharmacology (QSP) model to understand the mechanism behind this phenomenon. The model described the...

This study describes the antidiarrhoeal and bronchodilatory activities of Valeriana wallichii D.C. (Valerianaceae). The crude extract of V. wallichii (Vw.Cr) caused inhibition of castor oil-induced diarrhoea in mice at 300-600 mg kg⁻¹. In guinea-pig trachea, Vw.Cr concentration dependently (0.03-3.0 mg mL⁻¹) relaxed the low K+ (25 mM)-induced contractions, with a mild effect on the contractions...