The oxidation of ketones by monometallic [Pd(CH3CN)2(S)-Tol-BINAP](BF4)2 A or [Pd(CH3CN)2(S)-METBOX](BF4)2 B in aqueous THF containing copper(II) bromide produced chiral α-bromoketones. The α-bromoketone products were obtained with moderate to high enantiomeric excess (68-89% ee) and good isolated yields (70-90%). The highest optical purities were 89% ee for cycloheptanone. Catalyst B gave slig...

in this research, an efficient synthesis toward 2-(2-((4-methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2h)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (il) has been described. 1-methyl-3-pentylimidazolium bromide (il) has been employed as a recyclable green solvent. the work-up pro...

Mass spectrometric analysis of proteolysis products of haloenol lactone-modified glutathione S-transferase isozyme mGSTP1 indicates that the haloenol lactone 3-cinnamyl-5(E)-bromomethylidenetetrahydro-2-furanone is covalently attached to the protein at Cys-47. Comparisons of the extent of adduct formation with losses in enzymatic activity indicate that mGSTP1 exhibits greatest reactivity toward...

In this research, an efficient synthesis toward 2-(2-((4-Methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2H)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (IL) has been described. 1-Methyl-3-pentylimidazolium bromide (IL) has been employed as a recyclable green solvent. The work-up pro...