Caveolae are small invaginations of the cell membrane that are thought to play a role in important physiological functions such as cell surface signaling, endocytosis and intracellular cholesterol transport. Caveolin-1 is a key protein in these domains and contributes to the organization of cholesterol and saturated lipids within these vesicular invaginations of the plasma membrane. Caveolae ar...

Samantha Teplitzky is Earth and Physical Sciences Librarian in the Physics-Astronomy Library and Margaret Phillips is Social Sciences Librarian & BRII Coordinator in the Education/Psychology Library at the University of California, Berkeley; e-mail: [email protected], [email protected]. © 2016 Samantha Teplitzky and Margaret Phillips, Attribution-NonCommercial (http://creativeco...

Bone morphogenetic proteins (BMPs) play an important role during embryonic development, especially in chondrogenesis, osteogenesis, neurogenesis and hematopoiesis. There are over 19 BMPs known in mammalians, but only three BMP-type-I receptors and three BMP-type-II receptors are known so far to mediate these responses. Previous reports provide evidence to support that oligomerisation of BMP rec...

Abstract Background BRII-732, a prodrug of islatravir (ISL), is potent HIV-1 nucleotide reverse transcriptase translocation inhibitor. Following oral absorption, BRII-732 rapidly converted to ISL, which metabolized intracellularly the active metabolite, ISL triphosphate (ISL-TP). Single doses as low 0.5 mg significantly suppressed RNA by more than 1.0 log at day 7 in treatment-naive adults with...

Inflammatory and anti-inflammatory cytokines play an important role in the generation of effector and memory CD8 + T cells. We used two different models, transgenic expression of truncated (dominant negative) form of TGF-bRII (dnTGFbRII) and Cre-mediated deletion of the floxed TGF-bRII to examine the role of TGF-b signaling in the formation, function, and homeostatic proliferation of memory CD8...

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

Recent studies found that isolates of Toxoplasma gondii from Brazil were biologically and genetically different from those in North America and Europe. However, to date only a small number of isolates have been analysed from different animal hosts in Brazil. In the present study DNA samples of 46 T. gondii isolates from cats in 11 counties in São Paulo state, Brazil were genetically characteris...

Recent studies of Toxoplasma gondii isolates from animals in Brazil have revealed high genetic diversity. Many of these isolates are virulent to mice. It is speculated that these isolates may also be virulent to humans. However, there is very limited data regarding T. gondii strains from human infection. Therefore, it is not clear whether there is any association between parasite genotypes and ...