introduction the first medical intervention for many breast cancer patients is breast conserving surgery (bcs) and/or modified radical mastectomy (mrm). most of these patients undergo radiation therapy, following surgery. the most common side-effect of breast radiotherapy is skin damage. in the present study, the severity of acute skin changes and the underlying causes were investigated in pati...

background: tangential irradiation of intact breast is one of the most common procedures performed in any radiotherapy center. this method is performed by using 2d and 3d treatment planning. the aim of this study was to compare 2d with 3d plans in breast conserving radiotherapy. homogeneity of isodose, and lung received dose were compared. materials and methods: twenty patients with breast canc...

BACKGROUND Investigators of registry-based studies report improved survival for breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer. As these studies did not present long-term overall and breast cancer-specific survival, the effect of breast-conserving surgery plus radiotherapy might be overestimated. In this study, we aimed to evaluate 10 year overall an...

BCT: Breast Conserving Therapy; BCS: Breast Conserving Surgery; WBI: Whole Breast Irradiation; APBI: Accelerated Partial Breast Irradiation; START: Standardization of Breast Radiotherapy; ASBS: The American Society of Breast Surgeons; 3D-CRT: 3-Dimensional Conformal Radiotherapy; IMRT: Intensity Modulated Radiation Therapy; RTOG: Radiation Therapy Oncology Group; RAPID: Randomized Trial Of Acce...

BACKGROUND Adjuvant radiotherapy after breast-conserving surgery is indicated in the vast majority of breast cancer patients. Conventionally fractionated radiotherapy with 50 Gy in 25 fractions was considered standard of care for several decades. The recently publishes long-term results of randomized trials that have tested different moderately hypofractionated radiotherapy schedules that may c...

Ductal carcinoma in situ of the breast is associated with low mortality rates, but local relapse is a matter of concern in this disease. Risk factors for local relapse include young age, close or positive margins, and tumor necrosis. Whole breast irradiation following breast-conserving surgery for ductal carcinoma in situ significantly reduces the risk of local relapse as compared to breast-con...

Radiotherapy is an indispensible part of the management of all stages of breast cancer. In this article, the common indications for radiotherapy in the management of early breast cancer (stages 0, I, and II) are reviewed, including whole-breast radiotherapy as part of breast-conserving treatment for early invasive breast cancer and pre-invasive disease of ductal carcinoma in situ, post-mastecto...

BACKGROUND The objective of the study was to investigate whether radiotherapy or its omission after breast-conserving surgery has measurable consequences on local tumor growth and patient survival. METHODS We conducted a pooled analysis of published randomized clinical trials that compared radiotherapy versus no radiotherapy after breast-conserving surgery. The outcomes studied were ipsilater...

OBJECTIVES To determine if the length of interval between breast conserving surgery and start of radiotherapy affects local recurrence and to identify factors that might be associated with delay in older women with breast cancer. DESIGN Retrospective cohort analysis with Cox proportional hazards models to study the association between time to radiotherapy and local recurrence, and propensity ...

introduction: breast conserving radiotherapy is one of the most common procedures performed in any radiation oncology department. a tangential parallel-opposed pair is usually used for this purpose. this technique is performed using 2d or 3d treatment planning systems. the aim of this study was to compare 2d treatment planning with 3d treatment planning in tangential irradiation in breast conse...