objective(s): erythropoietin (epo), is a 34kda glycoprotein hormone, which belongs to type 1 cytokine superfamily. epo involves in erythrocyte maturation through inhibition of apoptosis in erythroid cells. besides its main function, protective effects of epo in heart and brain tissues have been reported. epo has a critical role in development, growth, and homeostasis of brain. furthermore epo h...

background: in previous studies, the neuroprotective effect of 17&beta-estradiol; in diffuse traumatic brain injury has been shown. this study used ici 182,780, a non-selective estrogen receptor antagonist, to test the hypothesis that the neuroprotective effect of 17&beta-estradiol; in traumatic brain injury is mediated by the estrogen receptors. methods: the ovariectomized rats were divided in...

traumatic brain injury (tbi) is an important cause of death and disability in young adults ,and may lead to physical disabilities and long-term cognitive, behavioral psychological and social defects. there is a lack of definite result about the effect of thyroid hormones after traumatic brain injury in the severity and no data about their effect on mortality of the injury. the aim of this study...

In previous studies, the neuroprotective effect of progestrone in diffuse traumatic brain injury has been shown. This study used mifepristone (RU-486), a potent progesterone receptor antagonist, to evaluatethe hypothesis that the neuroprotective effect of progesterone in traumatic brain injury is mediated by the progesterone receptors. The ovariectomized rats were divided into 6 groups. Brain i...

Introduction: Many theories have been proposed about the etiology of autism. One is related to brain connectivity in patients with autism. Several studies have reported brain connectivity changes in autism disease. This study was performed on Electroencephalogram (EEG) studies that evaluated patients with autism, using functional brain connectivity, and compared them with typically-developing i...

background: the effects of estrogene on central nervous system are still controversial. objective: we aimed to investigate the effects of raloxifene on the antioxidant enzyme [superoxide dismutase (sod) and catalase (cat)] activities and malondialdehyde (mda) levels in brain homogenates of ovariectomized female rats and its effect on cognitive process of learning. materials and methods: female ...

introduction: brain weight and cranial capacity are important parameters in the study of racial/ ethnic differences. this study was done to determine the effect of ethnicity on the female’s brain weight in northern iran. methods: brain weight was estimated using linear (lee–pearson’s) formula in 410 normal 17–20 year old (207 native fars and 203 turkman) females in northern iran. dimensions of ...

brain's waves are produced by spontaneous activity of neurons. these waves are changed by neurotransmitters in the central nervous system (cns). concentration of these neurotransmitters can be changed by various drugs and total power of brain waves also increase or decrease by these drugs. in this research effect of quinpirol and sulpiride on the brain waves was investigated. male wistar r...

Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...