Bradykinin (or kinin) receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on (kinin) Receptors [92]) are activated endogenous peptides bradykinin (BK), [des-Arg9]bradykinin, Lys-BK (kallidin), [des-Arg10]kallidin, [Phospho-Ser6]-Bradykinin, T-kinin (Ile-Ser-BK), [Hyp3]bradykinin and Lys-[Hyp3]-bradykinin. Variation in pharmacology activity of B1 B2 receptor antagonists at species or...

 Abstract Background: It has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. In the present study, the...

abstract background: it has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. in the present study, the ...

Zaltoprofen is a nonsteroidal anti-inflammatory drug used as an analgesic, antipyretic, and antinflammatory agent. It selective COX-2 inhibitor also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. prescribed for treating inflammatory conditions caused by various disorders such dental pain, musculoskeletal postoperative lumbar frozen shoulder, osteoarthritis cer...

Background: Bradykinin is the mediator responsible for local increase in vascular permeability hereditary angioedema (HAE; type I-II with low C1 inhibitor[C1-INH] level and/or function), and acquired (AAE). The current functional diagnostic assays employ complement inhibition, but there was no commercial physiological assay bradykinin pathway. Methods: We develop an ELISA using biotinylated kal...

The development of a "cytokine storm", characteristic severe COVID-19 forms, can be defined as state uncontrolled release large number inflammatory mediators. attachment SARS-CoV-2 S-glycoprotein to angiotensin-converting enzyme 2 is considered process that triggers complex molecular interactions lead hyperinflammation. In its turn, it realized through several systems: renin-angiotensin-aldoste...

introduction and aims: noscapine has been recently known as an antagonist of bradykinin, and in this study its effect on the animal model of acute pancreatitis has been evaluated. materials and methods: 49 male wistar rats have been evaluated in five experimental and four control groups. common bile duct has been ligated by means of surgery to induce acute pancreatitis in rats. the resulted inf...

The bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, we developed a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of bradykinin-(1-7), bradykinin-(1-8), and bradykinin-(1-9). Together with a carboxy terminal-directed...