introduction : deproteinized bovine bone mineral (bio-oss) is a xenogenic bone substitute, widely used in maxillofacial bone regeneration. the aim of this in vitro study was to investigate its influence on the growth behavior of human osteosarcoma cell line, saos-2 culture, and compare it with the physiologic dose of dexamethasone, an inductive factor for osteoblasts. materials and methods: hum...

the objective of this study was to evaluate the effect of accell connexus(®) on the quality and rate of healing in experimental defects of rabbit calvarium compared to bio-oss®.twelve 2.5-3.5 kg weighing new zealand white rabbits were used. three defects (3×6 mm) were created in the cranium of the animals subsequently filled with accell connexus(®), bio-oss® or served as controls. the animals w...

statement of problem: reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. platelet-rich plasma (prp) offers a new and potentially useful adjunct to bone substitute materials (e.g. xenografts) in oral and maxillofacial bone and implant reconstructive surgery. purpose: an animal study was carried out to investigate the influence of prp ...

BACKGROUND Recombinant human bone morphogenic protein-2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3-wall defect model and the clinical implications. METHODS The second and fourth mandibular premolars of four adult beagle dogs were...

Bovine and caprine Monterey Jack cheeses were produced unfortified (cheese) or fortified with milk calcium (Ca-cheese). Five groups of male rats were fed a control diet or one of four experimental diets: bovine cheese diet, bovine Ca-cheese diet, caprine cheese diet, and caprine Ca-cheese diet to test their effects on calcium absorption as well as bone mineralization. Significant differences (P...

Daily subcutaneous administration of bovine parathyroid hormone (PTH)(1-34) stimulates bone formation and increases bone mass in rat tibiae, femora and lumbar spine. However, the effects of PTH on the whole body bone mineral content and density determined by dual energy x-ray absortiometry (DEXA) have not been previously reported in rats. Eighteen-month-old intact female rats were subcutaneousl...

BACKGROUND Bone graft procedures have been used commonly in buco-maxillo-facial surgery. For this reason, many researchers have evaluated the bone substitutes. PURPOSE The present study evaluated soft and hard tissue reactions to two different hydroxyapatites HAs (synthetic HA and natural HA) and bioactive glass implanted into the sockets immediately after extraction. MATERIALS AND METHODS ...

STATEMENT OF PROBLEM The use of the platelet concentration technique is widespread in dental implant surgery. However, its effect or mechanism is not clearly understood. PURPOSE This study introduced an animal model for the platelet concentration technique and evaluated its effect on bone formation with natural cancellous bovine bone mineral. MATERIAL AND METHODS Adult New Zealand white rab...

The objective of this proof-of-principle study was to examine the potential for improved bone regenerative outcomes in maxillary sinus augmentation procedures when recombinant human platelet-derived growth factor BB (0.3 mg/mL) is combined with particulate anorganic bovine bone mineral. The surgical outcomes in all treated sites were uneventful at 6 to 8 months, with sufficient regenerated bone...