statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...

although some vitamins have been shown to prevent glucocorticoids induced osteoporosis in short time, the magnitude of this effect remains to be clarified. the aim of this study was to evaluate protective effect of vitamin d3 on methylprednisolone acetate (mpa) induced osteoporosis in rats. twenty-four male sprague dawley rats were randomly divided into four groups: group a (n = 6), was a base ...

glucocorticoid steroids are widely used as anti-inflammatory and immunosuppressive medications and are well known to induce osteoporosis. in present study 24 rats were randomly divided into four groups (n=6): group a (control), group b (sham)that was treated only by normal saline for 1 month.group c that was treated by methylprednisolone acetate alone (0.2 mg/kg) for 1 month. group d that was t...

abstract introduction : conjugated linoleic acid (cla) has been shown to positively influence on calcium and bone metabolism in experimental animals and cell culture, but there are limited human data available. material and methods : this double-blind, placebo-controlled trial study was done on 76 healthy post-menopausal women (aged 55.1) which randomly assigned to receive daily four cla capsul...

Biochemical markers of bone metabolism are divided into two groups: formation and resorption markers. Bone turnover is a dynamic process, which increases in postmenopausal period. Hormone replacement therapy (HRT) can diminish this increased bone turnover. Biochemical markers reflect acute changes in bone metabolism. Therefore, they may be very useful for the prediction of subsequent bone miner...

Introduction: Experimental evidence suggests positive effects of physical activity on skeletal mass. Biochemical markers determine the response rate of bone metabolism to physical activity. Therefore, the aim of this study was to investigate the effect of Pilates exercise training on serum osteocalcin and parathormone levels in inactive and overweight women. Methods: 28 healthy overweight wome...