mandibular defects may result from many conditions such as trauma, inflammatory diseases and tumors. there are rare cases reported in the literature that have demonstrated spontaneous bone regeneration after resection of the mandible. several factors such as age, preservation of the periosteum and genetics seem to influence spontaneous bone regeneration capacity in individuals. evaluation of th...

bone matrix gelatin (bmg) has been used for bone induction intramuscularly and subcutaneously by many investigators since 1965. more recently, some of the researchers have used bmg particles for bone repair and reported various results. in present study for evaluation of bone induction and new bone formation in parital defects, bmg particles were used in five groups of rats. the bmg was prepare...

many investigators use bone matrix gelatin for bone induction but it is used rarely for repair of teeth defects. this study was designed to evaluate secondary dentin formation by endochondral bone matrix gelatin (e-bmg) in rabbit. e-bmg was prepared from tibia and femur of 4 deutsche-poland rabbits with average ages of 4-6 months. the prepared e-bmg was implanted in right incisor teeth pulps of...

introduction : efforts are being made to improve the efficacy of biomaterials used as bone substitutes for bone regeneration in the oral and maxillofacial region. graft materials have been recently produced in iran; however, studies are required to confirm their efficacy. this study aimed to compare the histomorphometric results of using mineralized allografts produced by the hamanandsaz baft k...

background: it has been stated that the bone allografts from different tissue banks may lead to various amount of bone induction, so the aim of this study was to evaluate bone regeneration of three demineralized allografts both histologically and histomorphometrically in rabbits calvaria bone defects. materials and methods: in this double-blind randomized experimental animal study, 32 critical ...

conclusions p. gingivalis and p. intermedia could play a role in implant failure by changing the expression profiles of genes related to bone formation and resorption. results viability was reduced to 56.8% (p. gingivalis) and 52.75% (p. intermedia) at 1000 multiplicity. amongst 48 genes examined, expressions of bmper, smad1, il8 and nfrkb were found to be highly upregulated by both bacterial c...

conclusions alendronate may be considered a therapeutic option for improving the bone formation process and reducing resorption in different bone grafting procedures. further detailed studies should focus on dosage and time-dependent effects of alendronate on bone remodeling. results at 6 weeks, the bone area was significantly larger in the xenograft-alendronate group (33.0% ± 5.0%) than in the...

background and aims. statins, the mevalonate pathway inhibitors, have effects on bone formation in vitro and in vivo. the aim of the present study was to investigate whether injection of statins could lead to ectopic bone formation in rats. materials and methods. a single dose (0.5 mg) of simvastatin, atrovastatin, lovastatin and polyethylene glycol (control material) were injected into four qu...