PURPOSE To investigate the effect of desiccation on secretion of inflammatory cytokines in corneal epithelial cells and in the rat desiccation model. METHODS A human corneal epithelial cell line (CEPI) was grown in keratinocyte growth medium 2 (KGM2) to approximately 80% confluence. The medium was aspirated and dishes were left for 0 to 30 min with the cover left open to dry the cells (short-...

of the clinical presentation of the disease. The diagnosis can be suspected but not confirmed in the emergency depart­ ment (ED). In addition to recognizing the clinical presentation of tetanus, EPs play a vital role in the prevention of the disease. Primary pediatric vaccination and regular decennial booster vaccination are the mainstays of disease prevention and sever­ ity modulation. Herd im...

During the past years, we have witnessed an explosive growth in our capabilities to both generate and collect data. Advances in scientific data collection, the computerization of many businesses, and the recording (logging) of client’s access to networked resources have generated a vast amount of data. Various data mining techniques have been proposed and widely employed to discover valid, nove...

The axon initial segment (AIS) is a specialized region in neurons where action potentials are initiated. It is commonly assumed that this process requires a high density of voltage-gated sodium (Na1) channels. Paradoxically, the results of patch-clamp studies suggest that the Na1 channel density at the AIS is similar to that at the soma and proximal dendrites. Here we provide data obtained by a...

Motion area V5/MT+ shows a variety of characteristic visual responses, often linked to perception, which are heavily influenced by its rich connectivity with the primary visual cortex (V1). This human motion area also receives a number of inputs from other visual regions, including direct subcortical connections and callosal connections with the contralateral hemisphere. Little is currently kno...

Obesity is a critical health concern and although genetic factors may predispose an individual to become obese, changes in diet and lifestyle over the last few decades are likely to be significant contributors. Even so, it has been suggested that the causes of the current obesity crisis are not simply explained by changes in eating and exercise habits. Evidence suggests that the gut microbiota ...

Leg 178 will drill eight sites off the Pacific margin of the Antarctic Peninsula to provide a highresolution record of Antarctic continental climate over the past 6-10 m.y. and a direct check on the presumed glacio-eustatic origin of global sea-level change over the same period. Moreover, it is an essential preliminary to the more difficult task of extracting the complete Cenozoic record of Ant...