background: magnetic resonance imaging (mri) is a safe modality and useful in characterizing normal and abnormal bone marrow (bm). mri also presents a more global view of bm than biopsy therefore, it may provide a better understanding of hematologic disorders. the purpose of this study was to monitor radiation-induced alterations of bm in acute phase of irradiation (1-10 day after total body ir...

Background: Magnetic Resonance Imaging (MRI) is a safe modality and useful in characterizing normal and abnormal bone marrow (BM). MRI also presents a more global view of BM than biopsy therefore, it may provide a better understanding of hematologic disorders. The purpose of this study was to monitor radiation-induced alterations of BM in acute phase of irradiation (1-10 day after total body ir...

INTRODUCTION Severe trauma induces a profound elevation of catecholamines that is associated with bone marrow (BM) hematopoietic progenitor cell (HPC) colony growth suppression, excessive BM HPC mobilization, and a persistent anemia. Previously, propranolol (BB) use after injury and shock has been shown to prevent this BM dysfunction and improve hemoglobin levels. This study seeks to further in...

Infusion of parental lymph node (LN) cells into sublethally irradiated hybrid F1 recipients created a murine model for bone marrow (BM) failure. Affected animals developed fatal pancytopenia within 2 to 3 weeks, accompanied by BM oligoclonal T-cell infiltration and severe marrow hypoplasia indicated by approximately 10-fold declines in total BM cellularity, 15-fold declines in BM Lin(-)Sca1(+)c...

The administration of recombinant human interleukin-7 (rhIL-7) to mice twice a day for 7 days does not appreciably change bone marrow (BM) cellularity, but does result in a threefold to fivefold increase in the total number of leukocytes in the spleen, an eightfold to 10-fold increase in the total number of nonparenchymal cells (NPC) obtained from the liver, and up to a 20-fold increase in the ...

Sir, The differential diagnosis between hypocellular myelodysplasia (h-MDS) and aplastic anemia (AA) may be diffucult.1-5 In the present study we looked for new parameters that could be used for this purpose. Adult patients with pancytopenia and hypocellular bone marrow were studied. The criteria for h-MDS were: >5% of blasts in BM smears, ALIPs in BM sections, clonal cytogenetic abnormality or...

Aging of organ and abnormal tissue regeneration are recurrent problems in physiological and pathophysiological conditions. This is most crucial in case of high-turnover tissues, like bone marrow (BM). Using reciprocal transplantation experiments in mouse, we have shown that self-renewal potential of hematopoietic stem and progenitor cells (HSPCs) and BM cellularity are markedly influenced with ...

OBJECTIVE To study the main clinical and histopathological features of 12 patients with Hodgkin's lymphoma (HL) diagnosed primarily from bone marrow (BM) involvement. METHODS We included 12 acquired immunodeficiency syndrome (AIDS) patients with HL assisted in the F. J. Muñiz Infectious Diseases Hospital since January 2002 to December 2013. The diagnosis of HL with primary BM involvement in p...

In the present study we investigated the potential of the Sysmex XE-2100 automated hematology analyzer as a screening device for bone marrow (BM) aspirates. We evaluated BM cellularity, white blood cell (WBC) differential count, immature granulocyte (IG) count, nucleated red blood cell (NRBC) count, granulocyte/erythroid (G/E) and myeloid/erythroid (M/E) ratio, and potential pathologyrelated sc...

Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be activated by type I IFNs, TLR agonists, viruses, and bacteria to increase hematopoiesis. In this study, we report that endotoxin treatment in vivo induces TLR4, MyD88, and Toll/IL-1 resistance domain-containing adaptor-inducing IFN-beta (TRIF)-dependent expansion of BM HSPCs. Bacterial infection by Staphylococcus aureus or ...