The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the ...

Nanofiber mats have been widely applied in various biomedical fields such as drug delivery, tissue repair and wound dressing. In this study, the curcumin-loaded mesoporous silica incorporated nanofiber mats were prepared using blend electrospinning of curcumin-loaded mesoporous silica nanoparticles (CCM-MSNs) and polyvinyl pyrrolidone (PVP) for hemostasis. The prepared mats were then evaluated ...

The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of ...

Plant cell walls combine mechanical stiffness, strength and toughness despite a highly hydrated state. Inspired by this, a nanostructured cellulose network is combined with an almost viscous polysaccharide matrix in the form of a 50/50 amylopectin-glycerol blend. Homogeneous films with a microfibrillated cellulose (MFC) nanofiber content in the range of 10-70 wt % are successfully cast. Charact...

Staphylococcus aureus is a virulent pathogen and a major causative agent of superficial and invasive skin and soft tissue infections (SSSTIs). Antibiotic resistance in S. aureus, among other bacterial pathogens, has rapidly increased, and this is placing an enormous burden on the health care sector and has serious implications for infected individuals, especially immunocompromised patients. Alt...

objective(s): in this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  nanocomposite fibers including chitosan (cs)/poly (ethylene oxide) (peo) and antibiotic were successfully prepared using electrospinning. cs blended with peo considering a weight ratio of (90/10), and then, nanofibrous samples were successfully electrospun from their a...

electrically conducting nanofiber mats of polyaniline/copolyacrylonitrile (pani/ pan) blend in nmp were successfully fabricated using electrospinning technique. morphology and diameter of the nanofibers were studied by scanning electron microscope. structural characteristics of the electrospun nanofibers were examined using differential scanning calorimetry, fourier transform infrared spectrosc...

Nanomaterials are increasingly used to the targeting of gram-positive and gram-negative bacteria as an alternative to antibiotics. Bacterial infections are a major cause of chronic infections and mortality. People requirement for new materials for pathogenic bacteria treatment. It seems that nanomaterial-based strategies can be resolving this problem. In this research, improved antibacterial na...

In this research, a novel fixed-bed reactor was designed with a nanofiber membrane composed of a polyvinyl alcohol (PVA)/chitosan nanofiber blend prepared using an electrospinning technique. The applied voltage, tip-collector distance, and solution flow rate of the electrospinning process were 18 kV, 14.5 cm, and 0.5 mL h(-1), respectively. Brunauer-Emmett-Teller (BET) theory, scanning electron...

In this study, a blend mixture of chitosan-ethylenediaminetetraacetic acid (CS 2 wt%-EDTA) at a weight ratio of 30/70 and polyvinyl alcohol (PVA) solution (10 wt%) was electrospun to produce fibrous mats with lysozyme (10, 20 and 30 wt%) used for wound healing. The morphology and diameter of the electrospun fiber mats with and without lysozyme were analyzed by scanning electron microscopy (SEM)...