Bilateral primary spontaneous pneumothorax (PSP) is a rare case of lung disease. A 20-year-old man with complaint shortness breath suspected having PSP and tuberculosis. The patient underwent water seal drainage installation in both cavities, but showed no improvement. Multiple blebs were found after few days. wedge resection VATS became an option. had improved function the procedure. WSD lungs...

PURPOSE . To determine the role of extracellular matrix (ECM), transforming growth factor β (TGF-β) and metalloproteinase 9 (MMP-9) in mechanisms filtering bleb formation after non-penetrating deep sclerectomy (NPDS) patients with primary open-angle glaucoma (POAG). METHODS The study consisted prospective examination 65 POAG operated by NPDS method. Three groups were formed: group 1 — optimal h...

TITLE: Analysis of bleb morphology after trabeculectomy with anterior segment optical coherence tomography. PURPOSE: To describe the use of Anterior segment optical coherence tomography (AS OCT ) in imaging of trabeculectomy bleb to find out the morphology and internal structure, and correlate its internal characteristics with the function of the bleb. METHODS: Observational case-series study.6...

Melanoma cells have been shown to undergo fast amoeboid (leader bleb-based) migration, requiring a single large bleb for migration. In leader blebs, is rapid flow of cortical actin that drives the cell forward. Using RNAi, we find co-depleting cofilin-1 and depolymerizing factor (ADF) led increase in actin, suggesting both proteins regulate actin. Furthermore, severing factors can promote contr...

BACKGROUND AND PURPOSE Intracranial aneurysms with irregular shapes and blebs or secondary outpouchings have been correlated with increased rupture risk. The purpose of this study was to investigate possible associations between the local hemodynamics and the formation of blebs in cerebral aneurysms. MATERIALS AND METHODS Computational models of 20 cerebral aneurysms harboring 30 well-defined...

We have previously described a signaling complex (signalosome) associated with the GnRH receptor (GnRHR). We now report that GnRH induces bleb formation in the gonadotrope-derived LβT2 cells. The blebs appear within ~2 min at a turnover rate of ~2-3 blebs/min and last for at least 90 min. Formation of the blebs requires active ERK1/2 and RhoA-ROCK but not active c-Src. Although the following li...

OBJECTIVES To analyze and assess compatibility of trabeculectomy filtering bleb characteristics and appearances using biomicroscopy, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM). MATERIALS AND METHODS Twenty-eight eyes of 28 patients who underwent glaucoma filtering surgery with mitomycin C in our clinic between 2009 and 2013 were evaluated. Mo...

PURPOSE To determine the clinical features of tear fluid signs associated with filtration blebs via three-dimensional anterior segment optical coherence tomography (3D AS-OCT). METHODS In total, 152 eyes (130 patients) with glaucoma that underwent trabeculectomy with mitomycin C were evaluated retrospectively. We investigated tear fluid signs associated with filtration blebs, using 3D AS-OCT ...