The present investigation was aimed at studying the effect of incubation period, media, vitamins and solvents on biotransformation of albendazole by Cunninghamella blakesleeana. The transformation was evaluated and identified by high performance liquid chromatography (HPLC) and the structures of the transformed products were assigned by liquid chromatography-tandem mass spectrometry (LC/MS/MS) ...

To improve current bioaccumulation assessment methods, a methodology is developed, applied, and investigated for measuring in vivo biotransformation rates of hydrophobic organic substances in the body (soma) and gastrointestinal tract of the fish. The method resembles the Organisation for Economic Co-operation and Development (OECD) 305 dietary bioaccumulation test but includes reference chemic...

the present investigation was aimed at studying the effect of incubation period, media, vitamins and solvents on biotransformation of albendazole by cunninghamella blakesleeana. the transformation was evaluated and identified by high performance liquid chromatography (hplc) and the structures of the transformed products were assigned by liquid chromatography-tandem mass spectrometry (lc/ms/ms) ...

the great demand of people for consumption of natural additives resulted in producing natural vanillin. there are plant sources and chemical procedures for vanillin production but microbial bioconversions are being sought as a suitable alternative. in the present work, the ability to produce vanillin from isoeugenol was screened using growing cultures of various bacteria. among the 56 strains o...

Steroids are widespread in nature and are important compounds present in living systems. These compounds include different sterols, bile salts and steroid hormones like estrogen, androgens, testosterones etc. and have numerous therapeutic applications. Microbial biotransformation of steroids is one of the applications of microorganisms in the large-scale industries and it also have certain adva...

The ability of herbivores to switch diets is thought to be governed by biotransformation enzymes. To identify potential biotransformation enzymes, we conducted a large-scale study on the expression of biotransformation enzymes in herbivorous woodrats (Neotoma lepida). We compared gene expression in a woodrat population from the Great Basin that feeds on the ancestral diet of juniper to one from...

the abilities of silybum marianum cell culture to biotransform benzaldehyde to benzyl alcohol in three culture systems were compared. callus cultures of silybum marianum were established from seedlings, and healthy suspensions and immobilized cultures grown on the murashige and skoog medium. s. marianum cells were immobilized in both agar beads and fiber cotton matrixes. benzaldehyde was fed to...

mycoestrogen zearalenone (zea) is found in human foods and animal feeds. its estrogenic potencymainly depends on its biotransformation fate. the hepatic biotransformation of zea in rainbow trout wasinvestigated in this study. various concentrations of zea were separately incubated with the hepaticmicrosomal and post-mitochondrial sub-fractions in the presence of nadph, and the metabolites wered...

cell cultures of varthemia persica dc. have been studied to evaluate their abilities in biotransformation of aromatic and aliphatic precursors. v. persica (asteraceae) is an aromatic plant growing in iran. v. persica contain different terpens but its cell culture does not posses these compounds. callus cultures of v. persica was established from seedlings and healthy suspensions were grown usin...

Microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensis cells in the biotransformation of progesterone (I), a C-21 steroid hormone was studied for the first time.The fungal strain was i...