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LEARNING OBJECTIVES After studying this article, the participant should be able to: 1. Recognize the various terms used in biostatistics. 2. Describe the choices that are required in designing a particular research study. 3. Understand the different types of data that may be obtained in any given study. 4. Identify which statistical tools are appropriate for evaluating the different types of da...

False Discovery Rate (FDR) methodology, first put forward by Benjamini and Hochberg, and further developed by many authors including Storey, Tibshirani, and Efron is now one of the most widely used statistical methods in genomics, among other areas of application. A typical genomics workflow consists of i) estimating thousands of effects, and their associated p values; ii) feeding these p value...

Balance in the covariate distributions is crucial for an unconfounded descriptive or causal comparison between different groups. However, lack of overlap in the covariates is common in observational studies. This article focuses on weighting strategies for balancing covariates. We propose a general class of weights---the balancing weights---that balance the expectation of the covariates in the ...