CONTEXT AND OBJECTIVE Scientific and technological development is crucial for advancing the Brazilian health system and for promoting quality of life. The way in which the Brazilian Ministry of Health has supported clinical research to provide autonomy, self-sufficiency, competitiveness and innovation for the healthcare industrial production complex, in accordance with the National Policy on Sc...

OBJECTIVES Although ethics has been on the agenda in health technology assessment (HTA) since its inception, the integration of moral issues is still not standard and is performed in a vast variety of ways. Therefore, there is a need for a procedure for integrating moral issues in HTA. METHODS Literature review of existing approaches together with application of various theories in moral phil...

In 2014, balanced assessment systems (BAS) were proposed as a resource-conscious, 'fit-for-purpose' form of health technology assessment for middle-income countries which lack resources and competences necessary for resource-intensive health technology assessment models. BAS has undergone extensive policy debate in the period since its publication but it has not been critically assessed in a st...

This study provides a sociological commentary on the current debates within health technology assessment (HTA), specifically in response to the approaches taken in France, The Netherlands, Sweden, and the United Kingdom. It argues that HTA is part of a wider reflexive innovation system that seeks to order current and prospective technologies. The study discusses the socio-political process of H...

The new regulatory governance perspective has introduced several insights to the study of health technology assessment (HTA): it has broadened the scope for the analysis of HTA; it has provided a more sophisticated account of national diversity and the potential for cross-border policy learning; and, it has dissolved the distinction between HTA assessment and appraisal processes. In this paper,...

introduction: our aim was to compare the cost effectiveness of holmium laser prostate enucleation (holep) versus trans-urethral resection of prostate. methods:  we searched all available databases for any controlled trials comparing holep and turp from january 2000 to february 2009. two independent reviewers studied and appraised the selected evidences. then, effectiveness and cost effectivenes...

It is seen that the development of microfluidic laboratories working passively on chips has increased over years. The field microfluidics includes use microstructured devices, which typically have micrometer sizes and allow precise processing low volumes. Nano fields are main nanotechnology, science such as earth science, organic chemistry, molecular biology, semiconductor physics, micromachine...