The modern era of molecular biology began with the discovery of the double helical structure of DNA. Today, sequencing nucleic acids, the determination of genetic information at the most fundamental level, is a major tool of biological research [79]. This revolution in biology has created a huge amount of data at great speed by directly reading DNA sequences. The growth rate of data volume is e...

1 Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, 2 Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 3 Department of Biomedical Engineering, ...