endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...

Eliminativism is a peripheral (if not dead) position in the current biological function debate, and it roughly presented as thesis that terms are eliminable discourse. While eliminativism often assumed inadequate, detailed examination of lacking literature. Accordingly, this article provides critical eliminativism. This consists three parts: clarification supporting arguments for (based on hist...

the quantitative structure–activity relationship of a series of novel thiazoline derivatives with anticancer activity has been studied by using the density functional theory by b3lyp/ 6-31g. descriptors of quantum mechanics of 21 thiazoline derivatives with known activity were obtained. multiple linear regressions were employed to model the relationships between molecular descriptors and biolog...