summary: adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. it is characterized by high grade fever, skin rash, arthritis, leukocytosis, increased esr, crp and liver enzyme levels and high levels of ferritin. the treatment of aosd includes nsaids, steroids, and disease-modifying antirheumatic drugs (dmards). recently biologic agents have been used f...

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved by the US FDA for treatment of adults with moderate-to-severe plaque psoriasis who are candidates systemic therapy or phototherapy. Deucravacitinib was significantly more efficacious than placebo apremilast and well tolerated in previous reports from phase 3 POETYK PSO-1 trial. Here, we examin...

to the standard immunosuppressive treatment demonstrating its limitations and the current unmet need of, at least, similarly effective and less toxic treatment. To illustrate the close connection between a better understanding of the pathogenesis of the disease and targeted treatment, the papers on the pathogenesis of ANCA-associated vasculitis [2] , lupus nephritis [3] , the role of anti-PLA2R...

Although elbow tendinopathy is the one of common diseases causing pain, ideal nonoperative treatment to provide long-term satisfaction has not been introduced. Recently, there significant interest in biological facilitate healing environment and tissue proliferation tendinopathy. Biological agents such as platelet-rich plasma (PRP) or stem cells are likely be established methods that can have t...

Chronic Urticaria (CU) is a skin disorder characterized by wheal and flare with duration of more than 6 weeks affecting 1%-2% the population (more common in women). Thirty to 35% cases CU have angioedema [1]. The etiology chronic spontaneous urticarial not usually clear, 40%-50% are idiopathic 30%-40% autoimmune [2, 3]. Quality life disturbed which has direct relation severity [4].