introduction: due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191os-labeled 2-acetyl pyridine 4-n-methylthiosemicarbazone (191os-apmts) was investigated. methods: [191osmium (t½= 15.4d) was produced via the 190os(n,γ)191os nuclear reaction using enriched target irradiated with thermal neutrons. reaction of in-house synthesized 2-acetylpy...

introduction: somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (prrt). in this study, 177lu-[dota-dphe1, tyr3]octreotide (177lu-dotatoc) as an agent for prrt was prepared and its biodistribution was studied in rats. methods:the best condition for the preparation of the 177lu-dotatoc radiolabeled complex was det...

introduction: biodistribution study in animal models bearing tumors is one of the most important procedures in evaluation of fractional uptake of radiopharmaceuticals in the tumor and non-tumor organs. the aim of this study was to develop a new software-based method to determine activities that accumulate in the main organs as well as the tumor based on scintigraphy images, thereby obviating th...

objective(s):in this study, 166ho-1,2-propylene di-amino tetra(methy1enephosphonicacid) (166ho-pdtmp) complex  was prepared as a bone palliation agent. materials and methods:the complex was successfully prepared using an in-house synthesized edtmp ligand and 166hocl3. ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural ho(no3)3 samples  followed by radio...

introduction: the endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. methods:tc-99m labeled streptomycin was prepared using freshly milked 99mtco4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radiochemical purity shown by hplc/rtlc...

objective(s):   recently, applications of mno2 nanoparticles and microparticles in industry, pharmacology, and medicine have considerably expanded. mn distribution and clearance from brain and spinal cord tissue compared with muscle tissue of rats after single subcutaneous injection of nanoparticles and microparticle of mno2. pain sensory threshold of rat was evaluated as neurologic consequence...

Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study...

intoduction: therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. among some therapeutic radiopharmaceuticals, 166ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethylene phosphonic acid (166ho-dotmp) is us...

objective(s): in this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. materials and methods: lu-177 of 2.6-3 gbq/mg specific activity was obtained by irradiation of natural lu2o3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. the product was converted into chloride form which was further used for labeling of 177lu-phytate complex and che...

background: radiolabeled polyclonal human immunoglubins are useful in the detection of inflammations. in this work a novel approach has been presented to use thallium-201 as a comlexed nuclide for the development of radioimmunoconjugates. materials and methods: thallium-201 (t1/2=3.04 d) in tl+ form was converted to tl3+ cation in presence of o3 in 6m hcl, controlled by rtlc/gel electrophoresis...