MOTIVATION Biofuel cells (BFCs) based on enzymes and microbes are the promising future alternative sources of sustainable electrical energy under mild conditions (i.e. ambient temperature and neutral pH). By combining the adaptive behavior of BFCs self-regulating energy release with the versatility of biocomputing, we construct a novel gas-controlled biocomputing security system, which could be...

Although the term ‘Biocomputing’ may bring to mind biological replacements of silicon processors; this type of application is far in the future. Use of bacteria-based Biocomputing for biosensors and industrial fermentation control, however, is presently attainable by using genetically-engineered bacterial cells that can process signals in a logical operation via one or a few pathways. Here, we ...

Single Nucleotide Polymorphisms (SNPs) are the most common source of genetic variations. There has been enormous research in the area of Biocomputing and Bioinformatics on identification and analysis of SNPs. A large number of methods have been developed for their identification ever since the importance of SNPs in understanding of diseases emerged with the completion of Human Genome Project. T...

The goals of this workshop are to discuss challenges in explainability of current Machine Leaning and Deep Analytics (MLDA) used in biocomputing and to start the discussion on ways to improve it. We define explainability in MLDA as easy to use information explaining why and how the MLDA approach made its decisions. We believe that much greater effort is needed to address the issue of MLDA expla...

BACKGROUND As biologists increasingly rely upon computational tools, it is imperative that they be able to appropriately apply these tools and clearly understand the methods the tools employ. Such tools must have access to all the relevant data and knowledge and, in some sense, "understand" biology so that they can serve biologists' goals appropriately and "explain" in biological terms how resu...

This review article is an overview of the current state of the development of biochemical flip-flop memory systems for use with biocomputing. Of particular interest are those developed using chemical and biochemical systems and components, capable of the complete integration into existing biocomputing information processing systems. The integration of memory systems with sophisticated logic “ma...

Biocomputing is a broad field of research encompassing any area at the intersection of computing and biology. Bacterial biocomputing is a branch of biocomputing focused on generating bacterial strains with useful logical and sensing functions, using chemical, electrical, or physical input or output signals. Significant advances have been made in the last decade; however, there are major obstacl...