due to poor solubility in lipids, many of bioactive components (nutraceutical materials) show less bioactivity than optimal state in water solution. phytosomes improve absorption and bioavailability of biomaterials. liposomes, spherical shaped nanocarriers, were discovered in the 1960s by bangham. due to their composition, variability and structural properties, liposomes and phytosomes are extr...

In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compound. But a severe limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are recently introduced herbal f...

Natural products have limitation in the bioavailability of active components because numbers reasons which includes poor solubility ingredient, stability due to gastric and colonic acidity, metabolism by effect gut microflora, absorption across intestinal wall, efflux mechanism first-pass metabolic effects these factors make failure clinical trials efficacy natural phytochemicals used for human...

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...

Milk thistle extract is a well-known hepatoprotectant with low bioavailability (20-50%). The objective of the present study is to prepare and characterize silymarin phytosomes and to test the hepatoprotective effect of the phytosomes in CCl4 induced liver injury in rats compared to milk thistle extract. Phytosomes were prepared using lecithin from soybeans and from egg yolk. The prepared phytos...

several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bi...

Liposomes continue to attract great interest due their increased bioavailability in the body and because substances encapsulated are protected while maintaining effectiveness. The aim of this study is obtain “giant” liposomes by lipid film hydration using a preparation formula with two different phospholipids, phosphatidylcholine (PC) phosphatidylserine (PS). Firstly, macro- microscopic charact...

objective:platycladus orientalis or thuja orientalis is a native plant of iran different parts of which are used in the treatment of various diseases such as: gout, rheumatoid arthritis, common cold, cough, bronchitis, asthma, high blood pressure and hormonal disorders like hirsutism and baldness. also, various organs of this species have been used as appetizer. the purpose of this study was to...

The objective of the present study was to investigate the influence of the encapsulation efficiency and size of liposome on the oral bioavailability of griseofulvin-loaded liposomes. Griseofulvin-loaded liposomes with desired characteristics were prepared from pro-liposome using various techniques. To study the effect of encapsulation efficiency, three preparations of griseofulvin, namely, gris...

Certain of the water-soluble flavonoid molecules can be converted into lipid-compatible molecular complexes, aptly called phytosomes. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the outer cell membrane, and from there into the cell, finally reaching the blood. The fruit of the milk thistle plant (Silybum marianum, Family Asterac...