traumatic brain injury (tbi) is physical damage to the brain structure which has a high global rate of mortality and morbidity. tbi can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. microglia can differentiate into m1 macrophages or m2 macrophages following the changes in biochemical properties of brain tissue. m1 sub type ...

Abstract Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the origin behind biosynthetic development of Gilvocarcins, a class bioactive C ‐aryl glycoside natural products. More specifically, origins O ‐ ‐glycoside migration in evolution biosynthesis for these classes Angucycline antibiotic For stability reasons 5a‐carbasugar motif was used...

We have created a system in which synthetically produced novel bioactive peptides can be expressed in vivo in Escherichia coli. Twenty thousand of these peptides were screened and 21 inhibitors were found that could inhibit the growth of E. coli on minimal media. The inhibitors could be placed into one of two groups, 1-day inhibitors, which were partially inhibitory, and 2-day inhibitors, which...

Carbazole, discovered over 100 years ago, is a privileged heterocyclic motif whose electronic and structural features have allowed its derivatives to find numerous applications. In addition to its abundance in natural products and bioactive molecules, carbazole has been a key motif in the development of organic light-emitting materials because of its wide band gap, high luminescent efficiency, ...

Recent research has shown that fish residual materials contain a range of components with interesting biological activity. Therefore, there is a great potential in the marine bioprocess industry to utilize these by-products as starting material for generating more valuable products. The aim of the present study was to search for bioactive peptides (in particular small natural bioactive peptides...

A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated into illustrative dipeptides via the free amine and carboxylate respectively demonstrating its utility as a novel amino acid for peptide synthesis and offering a vehicle f...