both micronuclei (mn) and binuclei (bn) as well as rapd (random amplifying polymorphism of dna) assays are newly biomarkers which are well-introduced in toxic injury and related genotoxicity studies in bivalve, fishes and even humans. however, there is no record of such studies in iranian persian gulf coast line so far. for this propose, we analyzed frequency of mn and rapd patterns in gill cel...

both micronuclei (mn) and binuclei (bn) as well as rapd (random amplifying polymorphism of dna) assays are newly biomarkers which are well-introduced in toxic injury and related genotoxicity studies in bivalve, fishes and even humans. however, there is no record of such studies in iranian persian gulf coast line so far. for this propose, we analyzed frequency of mn and rapd patterns in gill ...

introduction: ionizing radiation induces various kinds of dna damage in which may lead to chromosomal aberrations (ca). inspite of growing importance in the risk assessment, the dose yield kinetics of ca and their implications for dose assessment are not well established in exposures to low level radiation. in the present study, cytochalasin-b blocked micronucleus assay and metaphase analysis w...

Survivin and securin proteins are overexpressed in most cancer cells that have been shown to regulate mitotic progression. In this study, we investigated the roles of survivin and securin on cytochalasin B, a cytokinesis blocker mediating the cytotoxicity and cell growth inhibition in human cancer cells. The human lung carcinoma cell lines A549 and H1299 highly expressed survivin proteins in mi...

BACKGROUND/AIMS Exposure to ionizing radiation can result in bone damage, including decreased osteocyte number and suppressed osteoblastic activity. However, molecular mechanisms remain to be elucidated, and effective prevention strategies are still limited. This study was to investigate whether cerium oxide nanoparticles (CeO2 NP) can protect MC3T3-E1 osteoblast-like cells from damaging effect...

The cytogenetic effects of chrysotile asbestos on Syrian hamster embryo cells in vitro were investigated at doses which induced morphological and neoplastic transformation but which failed to induce measurable gene mutations in the cells at two genetic loci. Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner. Up to 50% of the cells had...

In spite of wide spread investigations performed,the biological effects of ultrasound waves,specially on DNA molecule has not been fully understood.since any alteration in DNA molecule can lead to chromosome abnormality,the study of clastogenic effects of ultrasound is important.in this study,the effect of 1MHz frequency continuous waves with the power of 0.5,1 and 1.5 watts on G human lymphocy...

Dear Dr. Bedrossian: Differential diagnosis of a submucosal cecal mass discovered by colonoscopy includes neoplasms such as carcinoid, lymphoma, leiomyoma, gastrointestinal (GI) stromal tumor, and lipoma, among others. However, infectious processes such as tuberculosis, actinomycosis, and ameboma in the ileal–cecal regions have been reported presenting as masses mimicking tumors. Giardia is the...