A 5-year-old boy underwent orthotopic liver transplantation (OLT) for cirrhosis secondary to tyrosinemia. His immediate post-transplant course was unremarkable. After five months, he developed fever (T >38 °C). At that time, he was receiving tacrolimus, cellcept and prednisolone. His laboratory findings revealed an ALT of 85 IU/L, AST 86 IU/L, Alk-P 730 IU/L, total billirubin of 2.5 and direct ...

This study was carried out to investigate the effect of alcoholic extract of Lagerstroemia speciosa (L) pers. against carbon tetrachloride (CCl4) induced liver fibrosis in male albino Wistar rats (150-200gm). Liver fibrosis was induced by twice/week administration of CCl4 at a dose of 1ml/kg body weight, mixed with an equal volume of corn oil. The extent of liver fibrosis was assessed by the co...

Background: Beta thalassemia major (Cooley's anemia) is a congenital genetic blood disorder resulting from deficiency of β-globin chains due to severe anemia that depends on continuous transfusions for survival. Patients suffer hemoglobinopathy, infection, diabetes mellitus, growth retardation, enlargement and damage the liver spleen, bone marrow aplasia delayed sexual maturity. This complicati...

spreading for most of the areas including the health care and medical information. We have applied the data mining techniques, such as KNN, SVM, MLP or decision trees over a unique dataset, which is collected from 16,380 analysis results for a year. Furthermore we have also used meta-classifiers to question the increased correlation rate between the liver disorder and the liver analysis outputs...

Protective role of Gycyrrhiza glabra rhizomes (roots) at three dose levels (100, 75, & 50 mg/kg/bw) against sublethaldose (300 mg/kg/bw) of acetaminophen (paracetamol) induced hepatorenal damage has been assessed in mice. Parameters of study were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), billirubin, alkaline phosphatase (ALP) as liver function tests, crea...

Using herbal drugs is the common way for treatment of diseases in traditional and alternative medicine. These drugs have important role and strong cultural background among people in treatment of hyper-billirubinemia. It is necessary to evaluate the effect of herbal drugs by scientific methods. The goal of this study is evaluation the effect of common herbal drugs used in management of neonatal...

The objective of the present study was to investigate the hepatoprotective activity of methanol extract of Euphorbia neriifolia (MEEN) against paracetamol induced hepatotoxicity. Hepatotoxicity was induced in Wistar rats by oral administration of paracetamol (640 mg/kg suspended in 1% carboxy methyl cellulose), once during the 16 days treatment period. MEEN was administered orally at the doses ...

Dengue Fever (DF) is only rarely considered as a cause of acute liver failure even globally and only a few case reports of acute hepatic failure and encephalopathy occurring in DF in adults are available. We report a case of Acute Liver Failure due to Dengue during a major outbreak in 2010 in Chitwan. A 20 year old previously healthy female presented to the emergency department of Chitwan Medic...