Bax-interacting factor 1 (Bif-1, also known as endophilin B1) is a multifunctional protein involved in the regulation of apoptosis, mitochondrial morphology, and autophagy. Previous studies in non-neuronal cells have shown that Bif-1 is proapoptotic and promotes mitochondrial fragmentation. However, the role of Bif-1 in postmitotic neurons has not been investigated. In contrast to non-neuronal ...

The gene bifocal (bif), required for photoreceptor morphogenesis in the Drosophila compound eye, encodes a protein that is shown to interact with protein phosphatase 1 (PP1) using the yeast two-hybrid system. Complex formation between Bif and PP1 is supported by coprecipitation of the two proteins. Residues 992 to 995 (RVQF) in the carboxy-terminal region of Bif, which conform to the consensus ...

BACKGROUND/AIM Bax-interacting factor-1 (Bif-1) plays a crucial role in apoptosis and autophagy. The aim of this study was to evaluate Bif-1 protein expression and its prognostic significance in colorectal cancer (CRC). METHODS We analyzed Bif-1 protein expression in 251 resected specimens from patients with CRC by immunohistochemistry using tissue microarray. RESULTS Low Bif-1 expression w...

Misshapen (Msn) has been proposed to shut down Drosophila photoreceptor (R cell) growth cone motility in response to targeting signals linked by the SH2/SH3 adaptor protein Dock. Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn. Phenotypic analysis ...

− A Background Information Fusion (BIF) algorithm and its application in video target tracking is proposed in the paper. The BIF algorithm is based on the fact that there are redundant information between different frames. Unlike most of available tracking algorithms based on target features, which focus on the problems of what features the target have, and how does these features change when t...

We studied zircon from banded iron formations (BIFs) in the Kostomuksha greenstone belt (KGSB), Karelian Craton, for first time. Here, BIFs are associated with Mesoarchean basalt-komatiites – BIF-1 and felsic volcanics BIF-2, as well Neoarchean graywackes BIF-3. All contain accessory zircon. Analysis of its isotopic age shows presence 1-4 clusters each sample. There single grains detrital most ...

BACKGROUND There is little research on the subject of personality disorder (PD) in individuals with borderline intellectual functioning (BIF). Unlike in most countries, in the Netherlands, patients with BIF are eligible for specialized mental health care. This offers the unique possibility of examining the rates of PDs in patients, who in other countries are treated relatively invisibly in regu...

As an integral part of a porous framework and uniformly distributed throughout the internal pore space, the high density of the exposed B-H bond in zeolite-like porous BIF-20 (BIF = Boron Imidazolate Framework) is shown here to effectively produce nanoparticles within its confined pore space. Small noble-metal nanoparticles (Ag or Au) are directly synthesized into its pores without the need for...

Atg9 is a multispanning transmembrane protein that is required for autophagosome formation. During autophagy, vesicles containing Atg9 are generated through an unknown mechanism and delivered to the autophagosome formation sites. We have previously reported that Atg9-containing membranes undergo continuous tubulation and fission during nutrient starvation in a manner dependent on the curvature-...

Model selection is one of the key issues both in recent research and application of kernel methods. Cross-validation is a commonly employed and widely accepted model selection criterion. However, it requires multiple times of training the algorithm under consideration, which is computationally intensive. In this paper, we present a novel strategy for approximating the cross-validation based on ...