introduction: hypoparathyroidism (hpt) is an irreversible but preventable disorder caused by an iron overload which can be considered a typical complication in patients with beta-thalassemia major. patients and method: parathyroid function was evaluated in 130 patients in qom, iran, who suffered from beta-thalassemia major. their serum ferritin levels were checked for monitoring of chelation th...

peripheral blood t lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. three monoclonal antibodies (anti-cd3, anti cd-f, unti-cds) were simultaneously applied for detection of th (cd3-, cd4^), tsk (cd3+, cd8+) and th/ts ratio by flow-cytometry respectively. the results of this study sho...

introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...

background polypeptide hormone leptin suppresses inflammation in the heart muscle and protects heart from diseases. the purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. materials and methods in this cross-sectional study, 70 children with major thalassemia were selected. two ml blood ...

background: beta-thalassemia is considered to be the most frequent hereditary blood disorder worldwide. lipid abnormalities have been detected in different types of beta-thalassemia . the aim of this study is to assess the lipid profiles in beta-thalassemia major (btm) and beta-thalassemia intermedia (bti) patients in southern iran. methods: the study group consisted of 55 btm patients and 50 b...

abstract introduction : celiac disease (cd) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.  this study reports evaluated prevalence of cd in patients with beta-thalassemia major. materials and methods: in this case-control study in a period of 3 years  which was performed on 620 children in two groups of  beta-thalassemia major  patients (n=20...

background: major thalassemia is an autosomal recessive disease with complications, mortality and serious pathology. today, the life expectancy of patients with major thalassemia has increased along with therapeutic advances. therefore, they need lifelong care, and caring for them would incur many costs. being aware of the patients’ costs can be effective for controlling and managing the costs ...

inroduction: heart failure (hf) is an important cause of morbidity and mortality in the cases of beta-thalassemia major. the purpose of this study was to estimate hf prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy.   design and methods: this cross sectional study included 72 beta-thalassemia major cases, the mean age at the...

abstract objective thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. the objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. methods among 70 beta thalassemia patients, 50 were selected for chelating therapy usin...