A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and menisdaurin in the methanol extracts of aerial parts of Flueggea virosa (FVME). Chromatography was performed on glass-backed silica gel 60F254 HPTLC plates using dichloromethane: methanol as mobile phase. Scanning and quantification was done a...

Bergenin is a C-glucoside of 4-O-methyl gallic acid is a colourless crystalline polyphenol isolated from medicinal plants like Bergenial crassifolia (B. crassifolia), Mallotus philippinensis (M. philippinensis), Corylopsis spicata (C. spicata), Caesalpinia digyna (C. digyna), Mallotus japonicus (M. japonicus), Sacoglottis gabonensis (S. gabonensis) etc. It is hydrolyzable tannin and an isocouma...

Bergenin, isolated from the herb of Saxifraga stolonifera Curt. (Hu-Er-Cao), has anti-inflammatory, antitussive and wound healing activities. The aim of the present study was to identify the effect of bergenin on experimental colitis, and explored the related mechanisms. Our results showed that oral administration of bergenin remarkably alleviated disease symptoms of mice with dextran sulfate s...

Because previous chemical investigations have revealed the presence of bergenin and gallic acid as important bioactive components of Bergenia, a simple, highly precise RP-HPLC method coupled with photodiode-array detection has been developed and validated for simultaneous determination of these compounds in the Bergenia species B. ligulata (Wall) Eng., B. ciliata (Royle) Raizada, and B. strache...

Bergenin, a C-glucoside of 4-O-methyl gallic acid from Bergenia purpurascens, is a naturally antitussive and expectorant agent. A rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of the active component-bergenin, in rat plasma after oral administration of aqueous B. purpurascens extract. The plasma sample...

In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-galloylbergenin...

A new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1-8) in LPS-stimulated murin...

Tuberculosis (TB) remains one of the greatest health concerns worldwide, which has hindered socioeconomic development in certain parts of the world for many centuries. Although current TB therapy, "Directly Observed Treatment Short-course," is effective, it is associated with unwanted side effects and the risk for the generation of drug-resistant organisms. The majority of infected individuals ...

Bergenia species are evergreen herb belonging to the family saxifragaceae. The rhizomes of these plants are used in the indigenous system of medicines. There are three species of Bergenia, namely B. ligulata, B. ciliata and B. stracheyi. The rhizome and other parts of B. ligulata is used in urinary bladder stone, antilithic activity diuretic activity, anti-bradykinin activity, antiviral activit...