background today, the use of cyclodextrins (cds) is a major concern in drug formulations to improve solubility and stability of compounds. it has been known that cds can reduce the antimicrobial effectiveness of preservatives by formation of inclusion complexes. objectives in this study the interaction between commonly used preservatives, benzalkonium chloride (bzcl) or methyl paraben (mp), wit...

benzalkonium chloride is a quaternary ammounium compounds derivative under different names such as afxhang, hamoon, mahan etc, which have great and expanded use in sanitation and medical affairs. bactericidal activity of these disinfectants was fulfilled according to national standard method no.2842 on staph. aureus, sal. typhimouium and e. coli. this laboratory test showed that, except mahan t...

Benzalkonium bromides (BAK) are an important class of cationic surfactants with both industrial and commercial uses. They are used as preservatives for ophthalmic, nasal and parenteral products and they are also used as a topical antiseptic and medical equipment disinfectant. In this work a universal method for the preparation of these compounds is described. Using quaternization of N,N-dimethy...

conclusions bacterial resistance against quaternary ammonium compounds is increasing which can increase the bacterial biofilm formation. results the means of strains growth increase after the minimal inhibitory concentration (mic) were significant in all the bacteria (except for e. coli in 1/32 and s. agalactiae in of 1/8 mic). biofilm formation increased with decrease of antiseptics concentrat...

A set of new quaternary ammonium compounds based on pyridine-4-aldoxime was synthesized, characterized with analytical data (NMR, EA, HPLC, MS) and tested for in vitro antimicrobial activity (antibacterial, antifungal) and cytotoxicity. Quaternary pyridinium-4-aldoxime salts with length of alkyl side chain from C8 to C20 and belonging to the group of cationic surfactants were investigated in th...

Six automated instruments that measure sodium and potassium were tested for interference from two compounds used in catheters. Tridodecylmethylammonium heparin did not interfere with any of the methods. However, benzalkonium heparin falsely increased sodium measurement with the Kodak Ektachem, and falsely increased potassium measurements with three instruments (Beckman Astra, Baxter Paramax, an...

BACKGROUND Resistance toward quaternary ammonium compounds (QACs) is widespread among a diverse range of microorganisms and is facilitated by several mechanisms such as biofilm formation. OBJECTIVES In this study, the effects of benzalkonium chloride on planktonic growth and biofilm formation by some field isolates of animal bacterial pathogens were investigated. MATERIALS AND METHODS Forty...

OBJECTIVE To evaluate disinfectants for domestic use for the presence of bacteria, identify them, and determine their tolerance level to benzalkonium chloride. METHODS Fifty-two samples of commercially available disinfectants for domestic use were acquired at random in the metropolitan area of São Paulo, Brazil, and analyzed to detect the presence of bacterial contaminants. The isolated organ...

For surface disinfection in hospitals and nursing homes, preparations containing aldehydes such as formaldehyde, glutaral, or glyoxal, as well as quaternary ammonium compounds (QACs), are being used. Occupational allergic contact dermatitis (OACD), including airborne dermatitis, caused by these compounds is a well-known problem in nurses and hospital cleaners (1–6). For diagnostic purposes, onl...

Antimicrobial chemicals are widely applied in the food processing industry. In attention to extent uses of disinfectants, it is necessary to evaluate and certificate the efficacy of disinfectants and employing the minimum effective dosages. In this research the antibacterial influences of a common disinfectant solution used in food industry, benzalkonium chloride that is a quaternary ammonium c...