introduction bladder diverticulum is a result of bladder mucosa and submucosa herniation through the muscularis propria of bladder wall. bladder diverticula are mostly seen in the elderly men in association with benign prostatic hyperplasia (bph). case presentation a 74-year-old man presented with complaints of vague epigastric discomfort, dyspepsia, and mild lower urinary tract symptoms. an ul...

the tp53 gene is one of the most frequently mutated genes amongst human malignancies, particularly tp53 codon 72 polymorphism. furthermore, an association between the tp53 codon 72 variants and prostate cancer has been reported in several studies. although some studies have indicated an association between the tp53 arg/arg variant and an increased risk for prostate cancer, other studies have sh...

Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...

background : insulin-like growth factor-1 can act in both an autocrine and paracrine manner to promote normal growth and malignant cellular proliferation. the importance of this factor as a major regulatory peptide has been established for cells, in vitro and in vivo. however, the role of serum insulin-like growth factor-1 levels in the etiology of benign prostatic hyperplasia and prostate canc...

objective(s): prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

background : a single nucleotide variation within  atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...

results in a total of 40 sporadic prostate cancer and 80 benign prostatic hyperplasia cases, no xmrv was detected by real-time pcr and nested-pcr. rnase l r462q polymorphism analysis reveals that although there was an increase in the risk of prostate cancer correlated with the q/q allele of rnase l at position 462, the frequencies of the rnase l r462q alleles were not statistically significant ...