The human foamy virus (HFV) bel-1 transactivator protein was expressed in insect cells by a recombinant baculovirus. For the generation of the recombinant baculovirus, Acbel-1, the bel-1 gene of an HFV mutant was used, that bears truncations in the bel-1 overlapping bel-2 open reading frame. Acbel-1 infected Sf9 cells produced high amounts of recombinant protein of the same electrophoretic mobi...

1 Detection and Ignoring of Blackhole Attack in Vanets Networks; Chaima Bensaid, Computer Science Department, Djillali Liabes University at Sidi Bel Abbes, Sidi Bel Abbes, Algeria Sofiane Boukli Hacene, Computer Science Department, Djillali Liabes University at Sidi Bel Abbes, Sidi Bel Abbes, Algeria Kamel Mohamed Faraoun, Computer Science Department, Djillali Liabes University at Sidi Bel Abbe...

The Bel-1 transcriptional transactivator encoded by human foamy virus (HFV) can efficiently activate gene expression directed by both the HFV long terminal repeat (LTR) and internal (Int) promoter elements. By DNA footprinting and gel retardation analysis, we demonstrate that Bel-1 can specifically bind to discrete sites in both the LTR and Int promoter elements in vitro. However, transactivati...

This paper studies the combination of basic probability assignment (bpa) in evidence theory. After introducing an interpretation of the mass function we show that given two bpa Dempster's rule of combination does not build a coherent bpa with respect to the interpretation. Next we give a new combination function that overcomes this problems and study some of its properties. 0. Introduction One ...

Success in extracting biological relationships is mainly dependent on the complexity of the task as well as the availability of high-quality training data. Here, we describe the new corpora in the systems biology modeling language BEL for training and testing biological relationship extraction systems that we prepared for the BioCreative V BEL track. BEL was designed to capture relationships no...

BACKGROUND Hyaluronic acid (HA) fillers are sometimes mixed with lidocaine to mitigate pain. Whether the addition of epinephrine to lidocaine provides greater benefits in bruising and pain has not been fully reported. OBJECTIVES The investigators explored the severity of bruising and pain in patients treated with the cohesive polydensified matrix HA (CPMHA) in 3 different preparations: CPMHA ...

BACKGROUND To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods. METHODS Established human hepatocellular carcinoma adriamycin (ADM) multi-drug resistant cell sub-lines models Bel-7402/ADMV, Bel-7402/ADML and Bel-7402/ADMS by three methods of in vitro concentration gradie...

Recently, Bayesian extensions of Description Logics, and in particular the logic BEL, were introduced as a means of representing certain knowledge that depends on an uncertain context. In this paper we introduce a novel structure, called proof structure, that encodes the contextual information required to deduce subsumption relations from a BEL knowledge base. Using this structure, we show that...

In the present study, the in vitro cytotoxicity of daidzein was evaluated in human BEL-7402, A549, HeLa, HepG-2 and MG-63 cancer cell lines. BEL-7402 cells were sensitive to daidzein treatment, with an IC50 value of 59.7±8.1 µM. Daidzein showed no cytotoxic activity toward A549, HeLa, HepG-2 and MG-63 cells. Daidzein increased the levels of reactive oxygen species (ROS) and induced a decrease i...

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-type HDACi, has proved to be a promising cure in clinical trials for solid tumours and haematological malignancies. However, insight into molecular ef...