نتایج جستجو برای: beclin1

تعداد نتایج: 478  

ژورنال: Vaccine Research 2017
Abdoli , A, Aghasadeghi, MR, Amiran, MR, Khateri , M, Motevalli, F, Naziri , H, Tahmtan , A, Yavarian , J,

Introduction: Autophagy is a complicated process which is involved in many biological events such as antigen presentation by immune cells.  Beclin1, as a key component of autophagic machinery, plays the main role in the induction and initiation of this process. In the present study, we hypothesized that overexpression of Beclin1 could be useful in autophagy induction as an immunostimulatory str...

2017
Xia Wang Shu Li Shuhua Wu Lulu Xie Peiyuan Wang

Increasing evidence indicates that autophagy plays an important role in regulating proliferation and apoptosis in several human diseases, including cancer. Beclin1 is the first tumor-suppressor gene in mammals involved in the regulation of autophagy. However, the function of Beclin1 in oral cancer cells is not clear at present. We investigated the effects of Beclin1 on the biological characteri...

2013
Aditi U. Gurkar Kiki Chu Lakshmi Raj Richard Bouley Seung-Hwan Lee Young-Bum Kim Sandra E. Dunn Anna Mandinova Sam W. Lee

The Ser/Thr Rho kinase 1 (ROCK1) is known to have major roles in a wide range of cellular activities, including those involved in tumour metastasis and apoptosis. Here we identify an indispensable function of ROCK1 in metabolic stress-induced autophagy. Applying a proteomics approach, we characterize Beclin1, a proximal component of the phosphoinositide 3-kinase class III lipid-kinase complex t...

Journal: :archives of medical laboratory sciences 0
mahdieh talebi taravat bamdad ehsan arefian habib ahmadi hesam karimi hamzeh choobin

background: autophagy suppression recently has been known to have a remarkable effect for cellular adjustment and viability in the final stages of cancer. on the other hand, autophagy has the potential effect in preventing many viruses from replication. beclin1 is the most substantial constituent in autophagy apparatus regulation. this study was intended to investigate the beclin1 sirna knockdo...

Journal: :Cell 2011
Junli Liu Hongguang Xia Minsu Kim Lihua Xu Ying Li Lihong Zhang Yu Cai Helin Vakifahmetoglu Norberg Tao Zhang Tsuyoshi Furuya Minzhi Jin Zhimin Zhu Huanchen Wang Jia Yu Yanxia Li Yan Hao Augustine Choi Hengming Ke Dawei Ma Junying Yuan

Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific peptidases, USP10 and USP13, that target th...

2015
Paolo Tini Giuseppe Belmonte Marzia Toscano Clelia Miracco Silvia Palumbo Pierpaolo Pastina Giuseppe Battaglia Valerio Nardone Marie Aimée Gloria Munezero Butorano Armando Masucci Alfonso Cerase Luigi Pirtoli

Dysregulated EGFR in glioblastoma may inactivate the key autophagy protein Beclin1. Each of high EGFR and low Beclin1 protein expression, independently, has been associated with tumor progression and poor prognosis. High (H) compared to low (L) expression of EGFR and Beclin1 is here correlated with main clinical data in 117 patients after chemo- and radiotherapy. H-EGFR correlated with low Karn...

Journal: :Journal of virology 2012
D P Gladue V O'Donnell R Baker-Branstetter L G Holinka J M Pacheco I Fernandez-Sainz Z Lu E Brocchi B Baxt M E Piccone L Rodriguez M V Borca

Foot-and-mouth disease virus (FMDV), the causative agent of foot-and-mouth disease, is an Apthovirus within the Picornaviridae family. Replication of the virus occurs in association with replication complexes that are formed by host cell membrane rearrangements. The largest viral protein in the replication complex, 2C, is thought to have multiple roles during virus replication. However, studies...

Journal: :Oncology reports 2014
Lili Jiang Xuan Liang Mengjie Liu Wenjuan Wang Jiequn Ma Qianqian Guo Lili Han Chengcheng Yang Kejun Nan

Liver kinase B1 (LKB1) regulates cell polarity and has tumor-suppressor functions, while Beclin1 regulates autophagy and is associated with tumorigenesis. The present study quantified the expression level of LKB1 and Beclin1 in non-small cell lung cancer (NSCLC) tissue specimens and examined the possible association with clinicopathological characteristics and the survival of patients. Quantita...

Journal: :Gene Reports 2021

Rabies is an infectious viral disease without any cure. Autophagy considered as a method for reducing the damage to cell and its organelles. In some virus-infected cells, autophagy plays antiviral effect, while it acts in opposite manner other cells. Beclin1 (Atg6/Vps30) main regulator of autophagy. The present study aims build recombinant beclin1 stimulating evaluating effects mice infected wi...

Journal: :Molecular bioSystems 2013
Orsolya Kapuy P K Vinod József Mandl Gábor Bánhegyi

Decision-making between life and death is one of the most important tasks of cells to maintain their genetic integrity. While the surviving mechanism is driven by Beclin1-dependent autophagy, the suicide processes are controlled by caspases-mediated apoptosis. Interestingly, both these processes share regulators such as Bcl2 and influence each other through feedback loops. The physiological rel...

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