Data on eye irritation are generally needed for the hazard identification of chemicals. As the Bovine Corneal Opacity and Permeability (BCOP) test has been accepted by many regulatory agencies for the identification of corrosive and severe ocular irritants since September 2009 (OECD Test Guideline 437, TG 437), we evaluated this alternative method for routine testing at BASF. We demonstrated ou...

The bovine corneal opacity and permeability (BCOP) assay is an alternative method to the in vivo Draize eye test in rabbits for evaluating eye irritation in vitro. Here, we compared the numerical results of the BCOP assay with the corresponding histopathology for three different corneas for each test substance, including commercially available shampoos, make-up removers and cleansing foams that...

in Solid Tumor and Lymphoma Patients – An Observational Study in Singapore Xiao-Jun Wang, B.Sc.(Pharm)1; Mabel Wong, MD2; Li-Yang Hsu, MD3; Alexandre Chan, PharmD, BCPS, BCOP 1,4 1 Department of Pharmacy, Faculty of Science, National University of Singapore, 2 Department of Medical Oncology, National Cancer Centre, Singapore 3 Department of Medicine, National University Health System Singapore,...

Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. Protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. In...

In 2010, the Biologics Price Competition and Innovation (BPCI) Act was passed under the Patient Protection and Affordable Care Act (FDA, 2010). It created an abbreviated pathway for the approval of biologic products demonstrated to be clinically similar (or biosimilar) to or interchangeable with an approved reference product. A diverse panel of experts convened at JADPRO Live at APSHO to discus...

In situ gelling systems are becoming one of the most popular and well-known, with many potential benefits from delivery systems, such as ease use manufacture, improve adherence patient comfort by minimizing frequency drug administration. this review, we will describe characterization evaluation ophthalmic in gel preparation. Among them physical (appearance clarity, pH, isotonicity, gelation tem...

Molecular markers and the agents developed to target them have changed the landscape of non–small cell lung cancer (NSCLC) treatment. First-generation targeted agents have been proven to be more effective than chemotherapy in patients with certain driver mutations (i.e., EGFR, ALK) and the newest targeted agents are being developed to address the issue of resistance. Speakers at JADPRO Live at ...