background: bax and bcl-2 are the major members of bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. methods: in this study, the relative level of mrna expression of bax and bcl-2 genes was deter...

• BIRD-2 is an IP 3 R-derived peptide targeting Bcl-2’s BH4 domain, thereby disrupting R/Bcl-2 complexes. causes caspase-dependent cell death in diffuse large B-cell lymphoma lines. elicits apoptotic independently of the pro-apoptotic Bcl-2-family members Bim, Bax and Bak. BIRD-2-induced relies on mitochondrial Ca 2+ uptake permeability transition pore opening. Anti-apoptotic Bcl-2 critically c...

The Present study attempts to determine the relationship between proliferation and inhibition of apoptosis in normal endometrium hyperplasia, using monoclonal antibodies against marker, Ki-67 anti-apoptotic protein, Bcl-2 expression B-cell lymphoma 2 (Bcl – 2) Ki 67 cyclical proliferative secretory phase. includes Bcl endometrial hyperplasia.

ABSTRACT
 The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction compound, then carried out molecular docking confirm the potential biological ligands (vocangine, vobtusine, vobtusine lactone) against inhibition proteins (Bcl-2, Bcl-xL, Mcl-1), activation protein Bax apoptotic execution Caspase-3. This research is an experimental quantitativ...

The Bcl-2-family proteins have long been known for their role as key regulators of apoptosis. Overexpression various members the family is associated with oncogenesis. Its founding member, anti-apoptotic Bcl-2 regulates cell death at different levels, whereby emerged a major drug target to eradicate cancers through death. This resulted in development venetoclax, antagonist that acts BH3 mimetic...

the anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (i/r) injury. this experiment was designed to evaluate the role of folic acid in expression of bcl-2 in i/r in rat liver. eighteen wister rats were divided into sham-operated controlgroup (c) (n=6), i/r group (n=6), folic acid treated group whi...