BACKGROUND Recent studies have suggested that Bacille Calmette-Guerin (BCG) vaccination may have a non-specific beneficial effect on infant survival and that a BCG scar may be associated with lower child mortality. No study has previously examined the influence of BCG vaccination on cause of death. METHODS Two cohorts (A and B) were used to describe the mortality pattern for children with and...

OBJECTIVES To critically assess the prevalence among schoolchildren 6 to 9 years of age throughout the Dominican Republic of a bacille Calmette-Guérin (BCG) vaccination scar, and to examine the relationship between nutritional and sociodemographic factors and the likelihood of having a BCG scar. METHODS This correlational study used the database of the Second National Census on Height and Wei...

The policy of vaccinating children who live with leprosy patients, and who have responses to leprosin A of2rnrn or less, with BCG+killed Mycobacterium vaccae if they lack a BCG scar, or with killed M. vaccae alone if they have a BCG scar, has been followed over 3-4 years in two centers in Iran. Judged on the basis of skin test conversion to leprosin positivity, the policy has been highly su...

OBJECTIVE To compare the BCG size in asthmatic and nonasthmatic children. METHODS The size of BCG scar of two groups of children (the asthmatic group with a family history of some allergic disorder like asthma, atopic dermatitis, allergic rhinitis or allergic conjunctivitis in the first degree blood relatives and the control non asthmatic group with no history of any allergic disorder in the ...

BACKGROUND Previous studies have found that BCG vaccination has nonspecific beneficial effects on child survival, especially among children who developed a BCG scar. These studies have mostly been done in settings with a high scar frequency. In rural Guinea-Bissau, many children do not develop a scar; we tested the hypothesis that among BCG-vaccinated children, a vaccination scar was associated...

recent studies have proposed that a decline in bacterial infections such as tuberculosis is a factor underlying the rising prevalence and severity of atopic disorder in developed countries. there are conflicting ideas about the inverse relationship between bcg (bacillus calmette-guerin) vaccination and asthma. stronger response to tuberculin test as an indicator of more potent th1 response is s...

BACKGROUND The Bacillus Calmette-Guérin vaccine (BCG) against tuberculosis is administered intradermally, and vaccination is often followed by a scar at the injection site. Among BCG-vaccinated individuals, having a scar has been associated with lower mortality. We aimed to examine the impact of vaccination technique for scarring in a high income setting, by assessing the associations between t...

The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. beneficial off-target effects BCG are proposed to be stronger amongst children who develop a scar. Within an international randomised trial (‘BCG reduce the impact coronavirus disease 2019 (COVID-19) in healthcare workers’; BRACE Trial), this nested prospective cohort study assessed and factors...

INTRODUCTION Prenatal exposures such as infections and immunisation may influence infant responses. We had an opportunity to undertake an analysis of innate responses in infants within the context of a study investigating the effects of maternal mycobacterial exposures and infection on BCG vaccine-induced responses in Ugandan infants. MATERIAL AND METHODS Maternal and cord blood samples from ...

Bacillus Calmette–Guérin (BCG) vaccine provides good protection against disseminated mycobacterial diseases such as miliary tuberculosis, tuberculous meningitis, and leprosy [1, 2] but weaker protection against pulmonary tuberculosis, especially in rural areas near the equator [3]. In high-mortality countries, until a different vaccine is given, BCG vaccine also provides nonspecific (heterologo...