Cyclic di-GMP is a ubiquitous second messenger that regulates diverse cellular processes in bacteria by binding to various protein or riboswitch effectors. In Bacillus thuringiensis BMB171, a c-di-GMP riboswitch termed Bc2 RNA resides in the 5'-untranslated region (5'-UTR) of an mRNA that encodes a collagen adhesion protein (Cap). The expression of cap was strongly repressed in parent strain BM...

A murine antihuman factor IX monoclonal antibody (BC2) has been generated and evaluated for its capacity to prolong the activated partial thromboplastin time (aPTT) in vitro and ex vivo and to prevent arterial thrombosis in a rat model in vivo. BC2 extended aPTT to a maximum of 60 to 80 seconds at 100 to 1000 nmol/L in vitro (rat and human plasma, respectively) and ex vivo (rat) after dosing of...

Blastocyst MHC is a recently identified mouse MHC class Ib gene, which is selectively expressed in blastocyst and placenta, and may be the mouse homolog of HLA-G gene the products of which have been implicated in protection of fetal trophoblasts from maternal NK cells and evasion of some tumor cells from NK cell attack. In this study, we identified two blastocyst MHC gene transcripts encoding a...

The transition temperatures of epitaxial films of Fe(Te0:9Se0:1) are remarkably insensitive to applied magnetic field, leading to predictions of upper critical fields Bc2(T = 0) in excess of 100 T. Using pulsed magnetic fields, we find Bc2(0) to be on the order of 45 T, similar to values in bulk material and still in excess of the paramagnetic limit. The same films show strong magnetoresistance...

BACKGROUND Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) is an approach to biomarker discovery that combines chromatography and mass spectrometry. We aimed to consider the efficacy of Bc1, Bc2, and Bc3 serum biomarkers on early detection of breast cancer (BC) in this study. STUDY DESIGN In this prospective study, 91 patients who were admitted to our...

BACKGROUND Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to the RNA triplex poly(U)(•)poly(A)(*)poly(U) was studied by various biophysical techniques. METHODOLOGY/PRINCIPAL FINDINGS Berberine analogs bind to the RNA triplex non-cooperatively. The affinity of binding was remarkably high by about 5 and 15 times, respectively, for BC1 and BC2 compared to berberine. The s...

Recently it was demonstrated that Sr intercalation provides a new route to induce superconductivity in the topological insulator Bi2Se3. Topological superconductors are predicted to be unconventional with an odd-parity pairing symmetry. An adequate probe to test for unconventional superconductivity is the upper critical field, Bc2. For a standard BCS layered superconductor Bc2 shows an anisotro...

We report upper critical field Bc2(T ), resistivity, and Hall data for disordered (arsenic deficient) LaO0.9F0.1FeAs1−δ in a wide temperature and high field range up to 60 T. Due to the large linear initial slope of Bc2 ≈ -5.4 to -6.6T/K near Tc ≈ 28.5 K the T -dependence of the in-plane Bc2(T ) shows a clear flattening already near 23 K above 30 T which is intepreted as the onset of a Pauli-li...

We have employed uniaxial stress along the principal axes of the quasi-two dimensional organic superconductor κ–(BEDT-TTF)2Cu(SCN)2. The lattice anisotropy is thereby altered, with corresponding changes in the intermolecular transfer energies. The effect of uniaxial stress on the superconducting transition temperature Tc and critical field Bc2 is found to be anisotropic.There is an indication o...

Abbreviations and notes: N = nitrogen; Cu = copper; Fe = iron, Mn = manganese; Mo = molybdenum; Ni = nickel; Se = selenium; Zn = zinc. Sulfur is an essential macronutrient for plants and animals, and is required for many important metabolic functions. Plants are able to convert sulfate (SO 4 ) into organic compounds, but animals must consume S-containing amino acids (methionine and cysteine) fo...