alginate hydrogel and honey have a notably effect on wound healing process, therefore assessment of combined impact of those are essential. in this study, the effect of homey-based alginate hydrogel, alginate hydrogel and commercial alginate dressings in recovery of wound in a mouse model was studied. in this study, 20 wistar rats were divided into four groups of five. one wound with dimension ...

A novel hydrogel, based on an alginate/hyaluronate mixture and Ce(III) ions, with effective bioactive and antimicrobial ability was developed to be used as vehicle of a synthetic bone substitute producing an injectable substitute (IBS). Firstly, three different IBSs were prepared using three developed alginate-based hydrogels, the hydrogel Alg composed by alginate, the hydrogel Alg/Ch composed ...

Background: Achievement the new biocompatible wound dressing is one of the attractive areas of research. Objective: The present study attempts to examine the healing effects of the alginate - Persian mannaplant extract in the induced rat wounds. Methods: After culturing and detecting of the Pseudomonas aeroginosa strains by phenotyping and genotyping methods, the produced alginate was extra...

Development of the technique for constructing an internal perfusable vascular network is a challenging issue in fabrication of dense three-dimensional tissues in vitro. Here, we report a method for realizing it. We assembled small tissue (about 200 μm in diameter)-enclosing hydrogel microcapsules and a single hydrogel fiber, both covered with human vascular endothelial cells in a collagen gel. ...

Cell microencapsulation in alginate hydrogel has shown interesting applications in regenerative medicine and the biomedical field through implantation of encapsulated tissue or for bioartificial organ development. Although alginate solution is known to have low antiviral activity, the same property regarding alginate gel has not yet been studied. The aim of this work is to investigate the poten...

We present unique molding/bonding processes to fabricate microstructured Ca-alginate hydrogel plates. We employed propylene glycol alginate (PGA), an ester derivative of alginate, which suppresses the shrinkage of sodium alginate (NaA) during the gelation process, and prepared microstructured hydrogel plates via molding. Also, a bonding procedure utilizing polycation coating is presented to obt...

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the algi...

Oxidized sodium alginate is a handily modifiable polysaccharide owing to the pendant aldehyde groups which can form dynamic covalent bonds with amines, acylhydrazines, etc., providing oxidized sodium alginate-based hydrogels with stimuli-responsive properties. However, due to the stiffness and, in particular, the hydrophobicity of sodium alginate dialdehyde at low pH, the mechanical performance...

conclusions this study showed that compared to standard drug treatment, treatment with hydrogel containing peptide had substantial antibacterial effects on s. aureus wound infections in mice. results the highest and lowest numbers of wounds were observed on day 2 in the negative and positive control groups, respectively. during the 8-day period, the positive control and hydrogel containing pept...

The main goal of this study is to investigate a combination of viscosity-sensitive and viscosity-insensitive fluorescent dyes to distinguish different rheological states of hydrogel based biostructural materials and carriers in biological tissues and to assess their corresponding location areas. The research is done in the example of alginate hydrogel stained with viscosity-sensitive dyes Seta-...