infectious diseases are one of the most common causes of morbidity and mortality and the spread of resistant microorganisms is playing a significant role in this regard. the purpose of this study was to assess the trend in antimicrobial resistance of gram-positive bacteria at the main referral teaching hospital in tehran during a 4-year period. all patients' biological isolates such as blood, u...

nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. in view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

conclusions induction of coccoid form of p. aeruginosa may be one of the important reasons for antibiotic treatment failure; therefore, prescribed dose of antibiotics should be carefully managed to prevent increasing antibiotic resistance and coccoid bacteria induction. results all used antibiotics at sub mic concentration had capability to induce coccoid bacteria. the highest rate of induced c...

background: recent analyses of hospital outbreaks have documented the spread of resistance to imipenem, which is cur­rently a major problem among gram positive and gram-negative bacteria. the aim of this study was to describe the rate of gram- positive and gram-negative isolates resistance to imipenem as an antibiotic. methods: recorded files of 242 hospitalized patients with at least one sampl...

background mercury is one of the most toxic heavy metals. even a small amount of it is toxic for all living organisms. some of bacteria have developed special resistance mechanisms against mercury, in addition to resistant to different antibiotics. these bacteria usually acquire hg and antibiotic resistance genes via horizontal gene transfer in their habitat. objectives the aim of this study wa...

background & objective: urinary tract infection (uti) is a common disease in adults that early diagnosis and proper treatment of it has high importance. this study was performed for analysis of type and antibiotics resistance of isolated bacteria from urine of adult in different sex and ages for help in choose of antibiotics in empirical therapy.method: data of patients (gender, age, kind o...

background: integrons are the major reasons of multidrug resistance (mdr) among enteropathogenic bacteria. occurrence of horizontal gene transfer between integron-carrying microorganisms and other enteric bacteria may increase the rate of emergence of integron-associated antibiotic resistance. objectives: the objective of this study was to investigate class 1 integrons among members of enteropa...

results the k. pneumonia isolates were resistant to erythromycin (70%), cefixime (53.3%), tetracycline (50%) and ceftazidime (36.6%). the amplification of teta and tetb genes of k. pneumonia revealed that all of the isolates harbored these genes. conclusions resistance to tetracycline and other antibiotics, and the presence of various resistance genes in k. pneumonia strains are alarming signs ...

the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

conclusions with regards to the continuous changing in causative microorganisms isolated from patients with uti and antibiotic sensitivity patterns, it is recommended that bacterial sensitivity patterns in populations are determined in any region annually. . objectives this study aimed to detect and also compare the frequency and drug resistance pattern of gram negative bacteria isolated from p...