B3 is a murine monoclonal antibody (mAb) that recognizes a LewisY carbohydrate antigen present on the surface of many carcinomas. An imaging and Phase I trial was performed to study the ability of 111In-mAb B3 to image known metastasis and determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), kinetics, and biodistribution of 90Y-mAb B3. Patients (n = 26) with advanced epithe...

Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals: LP(B1)/EDG-1, LP(B2)/H218/AGR16/EDG-5, LP(B3)/EDG-3, LP(B4)/NRG-1/EDG-8, and LP(C1)/EDG-6. One of these receptors, LP(B1), has recently been shown to be essential for mouse embryonic development. Here we disrupted the lp(B3...

Toxoplasma gondii penetrates all kinds of nucleated eukaryotic cells but modulates host cells differently for its intracellular survival. In a previous study, we found out that serine protease inhibitors B3 and B4 (SERPIN B3/B4 because of their very high homology) were significantly induced in THP-1-derived macrophages infected with T. gondii through activation of STAT6. In this study, to evalu...

Cone photoreceptor cyclic nucleotide-gated (CNG) channels are thought to be tetrameric assemblies of CNGB3 (B3) and CNGA3 (A3) subunits. We have used functional and biochemical approaches to investigate the stoichiometry and arrangement of these subunits in recombinant channels. First, tandem dimers of linked subunits were used to constrain the order of CNGB3 and CNGA3 subunits; the properties ...

s2i;a1 ,s2i;b3 and s 2 i;a1 b3 , variances and covariance of random effects in parameters a1 and b3 at plot level; s2ij;a1 ,s2ij;b3 and s2ij;a1 b3 , variances and covariance of random effects in parameters a1 and b3 at tree level; σ , residual variance; δ parameter of power function. Note that the σ of the mixed-effects model must be multiplied by g = d when applied (variance obtained from ordi...

parent ACsEx.A Concrete children ACsEx.B1, ACsEx.B2, ACsEx1.B3 Class ACsEx.B1: Inherited methods B1.a2(), B1.a3(), B1.a4(P), B1.a7() Class ACsEx.B2: Inherited methods B2.a1(P), B2.a4(P), B2.a6(), B2.a7(), B2.a8(int) Class ACsEx1.B3: Inherited methods B3.a4(P), B3.a6(), B3.a7(), B3.a8(int) for the classes ACsEx.A, ACsEx.B1, ACsEx.B2, and ACsEx1.B3 from the code in Figure 1, the data in Table IV ...

The four encapsidated RNAs of brome mosaic virus (BMV; B1, B2, B3, and B4) contain a highly conserved 3' 200-nucleotide (nt) region encompassing the tRNA-like structure (TLS) which is required for packaging in vitro (Y. G. Choi, T. W. Dreher, and A. L. N. Rao, Proc. Natl. Acad. Sci. USA 99:655-660, 2002). To validate these observations in vivo, we performed packaging assays using Agrobacterium-...

B3 is a tumor-reactive monoclonal antibody (mAb) that binds to a limited number of normal tissues. Immunotoxins made with B3 coupled to either Pseudomonas exotoxin (PE) or recombinant forms of PE with a deletion of the cell-binding domain (LysPE40) have been shown to cause complete tumor regression in nude mice bearing a rapidly growing A431 (L. H. Pai et al., Proc. Natl. Acad. Sci. USA, 88: 33...

b3-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the b3-adrenoceptor, was discovered much later than b1and b2-adrenoceptors and exhibits unique properties which make extrapolation of findings from the other two subtypes difficult and the b3-adrenoceptor a less-understood subtype. This article discusses three aspects o...

Introduction Lessons captured from interviews with 12 European regions are represented in a new instrument, the B3-Maturity Model (B3-MM). B3-MM aims to assess maturity along 12 dimensions reflecting the various aspects that need to be managed in order to deliver integrated care. The objective of the study was to test the content validity of B3-MM as part of SCIROCCO (Scaling Integrated Care in...