The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

Brucellosis, produced by Brucella species, is a disease that causes severe economic losses for livestock farms worldwide Due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, a wide range of on-line prediction sof...

Brucellosis, caused by the genus Brucella bacterium, is a well-known infection among domestic animals. Considering the serious economic and medical consequences of this infection, various preventive efforts have been made through using recombinant vaccines, based on outer membrane protein (OMP) antigens of Brucella species. The objective of the present study was to clone, analyze the sequence, ...

background: boophilus tick is responsible for the transmission of some pathogens (types of germs) and the reduction of fertility in cattles. tropomyosin protein plays an important role in regulating actin function, immune and allergic reactions and vaccine production. objectives: accurate identification of antigenic determinants (epitopes) is difficult, time consuming and not economic, thus we ...

Background: Due to high genetic variation in human leukocyte antigen )HLA( alleles, epitope-based vaccines don’t show equal efficacy in different human populations. therefore, we proposed a multi-epitope vaccine against SARS-CoV-2 for Iranian populations. Materials and Methods: For this purpose, the proteins without allergenicity and high antigenicity as well as conservancy level from SARS-CoV...

conclusions this study provided conserved b-cell epitopes and peptides that can be useful for designing entry inhibitors and vaccines able to cover a global population, especially where genotype 5a is common. results differences in the probability of glycosylation in e1 and e2 regions were observed in this study. three conserved antigenic b-cell epitopes were predicted in the e2 regions and als...

brucellosis, produced by brucella species, is a disease that causes severe economic losses for livestock farms worldwide due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on brucella outer membrane protein (omp) antigens. in the present study, a wide range of on-line prediction sof...

conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

Background: Hepatitis C virus (HCV) causes acute and chronic human hepatitis infections. Due to the high genetic diversity and high rates of mutations in the genetic material so far there is no approved vaccine against HCV. Materials and Methods: The aim of this study was to determination B and T cell conserved epitopes of E1 and E2 proteins from HCV and construction of a chimeric pepti...