Naturally-occurring antisperm antibodies in men are a relative cause of infertility, being the fertility impairment related with the degree of sperm autoimmunization. The impairment of sperm penetration through the cervical mucus represents the best established mechanism of the antibody interference with fertility. Another mechanism may involve complement-mediated sperm injury and opsonizing ef...

Naturally-occurring anti-sperm antibodies (ASA) in men can affect fertility by various mechanisms. Some of them are mainly related to the extent of the sperm autoimmunization (e.g., sperm-agglutination and impaired cervical mucus penetration); others are also related to immunoglobulin (Ig)-isotype (e.g., complement-mediated sperm injury through the female genital tract), or to antigenic specifi...

Multiple sclerosis (MS) is a T-lymphocyte-mediated autoimmune disease that is characterized by inflammation in the central nervous system (CNS). Although many disease-modifying therapies (DMTs) are presumed effective in patients with MS, studies on the efficacy and safety of DMTs for preventing MS relapse are limited. Therefore, we tested the immunosuppressive anti-inflammatory effects of oral-...

Introduction. Red blood cell (RBC) alloimmunization and autoimmunization remain a major problem in transfusion dependent thalassemic patients. There is a paucity of data on the incidence of RBC alloimmunization and autoimmunization in thalassemic patients from eastern part of India, as pretransfusion antibody screening is not routinely performed. Aims. To assess the incidence of RBC alloimmuniz...

background: the development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. also, autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. we studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in ilam province...

W HEN an animal of one species is injected with the serum, tissues or blood cells of another, it forms antibodies against the injected material; this is known as heteroimmunization. Likewise, animals of one species, when injected with cells or tissues of animals of the same species, usually react immunologically; thus is isoimmunization. Thus, Ehrlich and Morgenroth,’ when they injected red cel...