antineutrophil cytoplasmic autoantibodies were detected in patients with some autoimmune and vascular disease such as wegner’s granulomatosis polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique was employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic autoantibodies were seen: a cytoplasmic (c-anca) a...

Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-co...

background chronic hepatitis c virus (hcv) is associated with extra hepatic autoimmune disorders, while peg-ifna-2a/rbv combination therapy may exacerbate these conditions. autoantibodies to cytoplasmic structures, called rod and ring particles (rr), have strong associations with these patients and are identified by hep-2 cells. objectives our purpose was to study the correlation of autoantibod...

Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form ...

For the evaluation of autoantibodies in Pemphigus vulgaris (PV), an indirect ELISA assay was developed by using a semi-purified human epidermal skin extracted with approximately a molecular weight (M.W.) of 130-160 kDa. The evaluation of Pemphigus IgG, IgM and IgA autoantibodies in 75 patients and 50 control sera indicated that this indirect ELISA assay was a useful method for the detection of ...

sjogren syndrome (ss) can occur alone, primary sjogren syndrome, or in association with other rheumatic diseases, secondary sjogren syndrome (sss), such as rheumatoid arthritis (ra). the occurrence of sjogren syndrome with ra makes it course worse and increases high morbidity and mortality of ra. in this exploratory study we aim to determine the prevalence of sss (diagnosed based on the revised...

background: immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. this study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...

background: alopecia areata (aa) is a noncicatricial (nonscarring) alopecia. the association between aa and celiac disease (cd) is debatable. several studies declare the relationship between aa and cd as measurement of celiac autoantibodies (anti‑gliadin iga and anti‑gliadin igg), but a few studies consider anti‑tissue transglutaminase iga. the aim of this study was to evaluate the frequency di...

objective: evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents and adverse pregnancy outcomes, via induced systemic inflammatory mediators' production. some authors have concluded that increase in systemic inflammatory markers occurs together with increase in serum levels of auto antibodies including anti-cardiolipin antibody (acla). the aim of the pre...