patients with valvular heart disease and suffering atrial fibrillation of more than 12 months duration have a low probability of remaining in sinus rhythm after valve surgery alone. we performed intra-operative radiofrequency ablation or cryoablation as an alternative to surgical maze ііі procedure to create linear lesion lines for conversion of this arrhythmia to sinus rhythm. a total of 30 pa...

An effective risk stratification which could help us identify high-risk patients who should take oral anticoagulants (OACs) is the key step for stroke prevention in atrial fibrillation (SPAF). Several scoring systems were available to estimate the risk of stroke in AF, including CHADS2, CHA2DS2-VASc, R2CHADS2 and ATRIA scores, which were constituted of different clinical risk factors. Recently,...

objectives in order to provide a pharmacological profile for some newly synthesized dihydropyridines, we investigated their effects on the isolated rat colon segments and the isolated rat atrium contractility. the tested compounds include alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-alkylthio-1-benzyl-5-imidazolyl substituent, and nife...

the prevalence of atrial fibrillation (af) is 1-2 % in the general population, and the risk of embolic stroke in af patients is 4-5 times higher than that in the general population. af-related strokes are often severe, and the rate of permanent disability is much higher among individuals who have af-related strokes than in those who have strokes unrelated to af. in patients with af, more than 9...

giant left atria are defined as those measuring larger than 8 cm and are typically found in patients who have rheumatic mitral valve disease with severe regurgitation. enlargement of the left atrium may create compression of the surrounding structures such as the esophagus, pulmonary veins, respiratory tract, lung, inferior vena cava, recurrent laryngeal nerve, and thoracic vertebrae and lead t...

It has been shown that atrial natriuretic peptide (ANP) influences proliferation of cardiac cells. To define the possible role of C-type natriuretic peptide (CNP) in cardiac hypertrophy, the influence of CNP on the secretion of ANP was studied with the use of perfused nonbeating atria from monocrotaline-treated rats. Increases in atrial volume caused proportional increases in ANP secretion that...

Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...

sodium valproate (sv), an antiepileptic drug has several mechanism of action. it inhibits voltage sensitive na+ channels and reduces intracellular na accumulation. these actions are similar to that of both phenytoin and carbamazepine. we have investigated the direct cardiac action of sv and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. the guinea-pig atrium was dissect...