نتایج جستجو برای: atra

تعداد نتایج: 1939  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه ارومیه - دانشکده دامپزشکی 1391
اصغر مرواریدی, نوروز دلیرژ,

القاء بیماری eae از طریق ایمن سازی با پپتید mog وادجوانت کامل فروند در موشهای ماده c57bl/6 انجام شد.درمان با atra در گروه درمانی پس از بروز علائم درمانگاهی آغاز گشت.علائم تا زمان کشتار ثبت شد.سپس میزان تولید نیتریک اکساید در محیط کشت سلولهای طحالی و ظرفیت تام آنتی اکسیدانی سرم موشها سنجیده شد.تولید no در گروه تحت درمان با atra بطور معنی داری کاهش یافت.همچنین درمان با atra از کاهش ظرفیت آنتی اکس...

15 صفحه اول
ژورنال: پیاورد سلامت 2014
غفاری, سید حمیداله, حسنی, سعید, صباغی, محمد, کاظمی, احمد, علی مقدم, کامران, قوام زاده, اردشیر,

Background and Aim: Acute promyelocytic leukemia (APL) is a distinct type of leukemia which is caused due to a blockage in myeloid cells normal maturation. The most important therapeutic strategies include the use of ATRA and Arsenic trioxide. Although ATRA is generally well tolerated, some patients develop Retinoic acid syndrome. Some of the symptoms of this syndrome are directly or indirectly...

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Journal: :Molecular pharmacology 2015
Ariel R Topletz Sasmita Tripathy Robert S Foti Jakob A Shimshoni Wendel L Nelson Nina Isoherranen

All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have biologic activity. Hence, CYP26A1, the main atRA hydroxylase, may function either to deplete bioactive re...

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Journal: :The Journal of pharmacology and experimental therapeutics 2017
Jing Jing Cara Nelson Jisun Paik Yoshiyuki Shirasaka John K Amory Nina Isoherranen

All-trans retinoic acid (atRA) is a front-line treatment of acute promyelocytic leukemia (APL). Due to its activity in regulating the cell cycle, it has also been evaluated for the treatment of other cancers. However, the efficacy of atRA has been limited by atRA inducing its own metabolism during therapy, resulting in a decrease of atRA exposure during continuous dosing. Frequent relapse occur...

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Journal: :Cukurova Medical Journal 2021

used in the treatment of various tumors. Retinoic acid has potent antioxidant effects. In this study, it is aimed to reveal effects all-trans retinoic (ATRA) on CP induced cardiotoxicity.
 Materials and Methods: wistar albino rats were used. Control group received single daily doses 1 ml/kg saline ATRA ATRA(7,5mg/kg/day) intraperitoneally (i.p.) for 10 days. ATRA+CP a dose CP(7mg/kg) i.p. ...

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Journal: :Cancer research 1993
J Drach G Lopez-Berestein T McQueen M Andreeff K Mehta

All-trans-retinoic acid (ATRA) induces complete remissions in the majority of patients with acute promyelocytic leukemia. Despite continuous p.o. ATRA administration, many patients relapse after a short remission duration. In these patients, ATRA plasma concentrations were found to be very low, which was related to induction of retinoic acid-binding protein and increased drug catabolism by cyto...

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2006
Dong-Gon Kim Changyong Choi Young-Il Jeong Mi-Kyeong Jang Jae-Woon Nah

The purpose of this study is to develop novel nanoparticles based on polyion complex formation between low molecular weight water-soluble chitosan (LMWSC) and all-trans retinoic acid (atRA). LMWSC nanoparticles encapsulating atRA based on polyion complex were prepared by mixing of atRA into LMWSC aqueous solution using ultrasonication. In FTIR spectra, the carbonyl group of atRA at 1690 cm disa...

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Journal: :Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2013
Francesco Lo-Coco Giuseppe Avvisati Marco Vignetti Christian Thiede Sonia Maria Orlando Simona Iacobelli Felicetto Ferrara Paola Fazi Laura Cicconi Eros Di Bona Giorgina Specchia Simona Sica Mariadomenica Divona Alessandro Levis Walter Fiedler Elisa Cerqui Massimo Breccia Giuseppe Fioritoni Helmut R Salih Mario Cazzola Lorella Melillo Angelo M Carella Christian H Brandts Enrica Morra Marie von Lilienfeld-Toal Bernd Hertenstein Mohammed Wattad Michael Lübbert Matthias Hänel Norbert Schmitz Hartmut Link Maria Grazia Kropp Alessandro Rambaldi Giorgio La Nasa Mario Luppi Fabio Ciceri Olimpia Finizio Adriano Venditti Francesco Fabbiano Konstanze Döhner Michaela Sauer Arnold Ganser Sergio Amadori Franco Mandelli Hartmut Döhner Gerhard Ehninger Richard F Schlenk Uwe Platzbecker

BACKGROUND All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity. METHODS We conducted a phase 3, multicenter trial comparing ATRA plus chemotherapy with ATRA plus arsen...

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Journal: :Drug metabolism and disposition: the biological fate of chemicals 2017
Faith Stevison Cathryn Hogarth Sasmita Tripathy Travis Kent Nina Isoherranen

All-trans retinoic acid (atRA), the active metabolite of vitamin A, is a ligand for several nuclear receptors and acts as a critical regulator of many physiologic processes. The cytochrome P450 family 26 (CYP26) enzymes are responsible for atRA clearance, and are potential drug targets to increase concentrations of endogenous atRA in a tissue-specific manner. Talarozole is a potent inhibitor of...

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Journal: :Blood 2003
Michael Witcher Douglas T Ross Caroline Rousseau Leslie Deluca Wilson H Miller

The nuclear receptor ligand all-trans retinoic acid (ATRA) causes dramatic terminal differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients, but it is less active in other malignancies. However, downstream mediators of the effects of ATRA are not well understood. We used a cDNA microarray to search for ATRA-regulated genes in the APL cell line NB4 and found that ATR...

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