background: a precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques , which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. we developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to charac...

objective(s):atherosclerosis is chronic inflammatory process triggered by oxidative stress. oxidative stress can increase hydrogen peroxide (h2o2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (pvat), foam cells, and atherosclerotic plaque. antioxidant is needed to control negative effects of oxidative stress. one source of antioxidant...

the aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. control group consisted of 27 patients, without carotid atherosclerosis. atherosclerotic pla...

Objective(s):Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidative stress. One source of antioxidant...

OBJECTIVE Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events. This review aimed to explore research progress on the risk factors and outcomes of human carotid atherosclerotic plaques, and the molecular and c...

Ghrelin has been found to be associated with anti-inflammatory effects, inhibition of atherosclerotic plaque formation, and plaque stability in the cardiovascular system. We investigated whether ghrelin affected atherosclerotic plaque and inflammation found in atherosclerosis. We crossed ghrelin receptor knock out mice (growth hormone secretagogue receptor (GHSR)-/-) and low-density lipoprotein...