background & aim: when the level of free radicals is increased and also when both the enzymatic systems and low molecular antioxidants are not sufficient to protect the organism, it seems necessary to get antioxidants from external sources. this study aimed to evaluate the antioxidant potential of different parts of catharantus roseus experimental: the antioxidant potential of ethanol extra...

Catharanthus roseus is well known for its pharmacological significance. The present study aims to determine the antifungal activity of Catharanthus roseus against various clinically significant fungal strains (Candida albicans, Aspergillus fumigatus, Aspergillus niger, Fusarium moniliforme). Assessment of antifungal activity of Catharanthus roseus was done by paper disc diffusion method. In thi...

The Catharanthus roseus L. plant leaf extracts were prepared by using solvents such as acetone, ethanol, and chloroform and tested against pathogenic microorganisms to determine their antimicrobial potential. Catharanthus roseus leaf extracts showed maximum antibacterial activity against all the pathogenic microorganisms. Among the solvents tested, ethanol showed maximum antibacterial activity ...

BACKGROUND AND AIMS Catharanthus roseus is a highly valuable medicinal plant producing several terpenoid indole alkaloids (TIAs) with pharmaceutical applications, including the anticancer agents vinblastine and vincristine. Due to the interest in its TIAs, C. roseus is one of the most extensively studied medicinal plants and has become a model species for the study of plant secondary metabolism...

Herbal medicine industry in Indonesia was shaken when Indonesian National Agency of Drugs and Food control prohibits the development of herbal medicines made from Catharanthus roseus. The reason given is that Catharanthus roseus contains alkaloids causing bone marrow depression. The purpose of this article to explore the effects of both preclinical and clinical pharmacological of Catharanthus r...

High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The aim of the present study was to investigate whether Catharanthus roseus (L.) G. Don (Apocynaceae) leaf powder alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. Adult male Wistar rats of body weight around 200 g were divided in...

One of the most characteristic and abundant amphibian taxa of South American temperate forests is Eupsophus. The ten currently recognized species of the genus have been divided in two species groups, roseus and vertebralis, but most of them, eight, belong to the roseus group. Recent phylogeographic and phylogenetic studies have suggested that species diversity of the roseus group could be under...

BACKGROUND The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. METHODS The blood glucose lowering activity of the leaf juice was studied in ...

The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C. roseus was carried out to identify the pathways and enzymes (genes) involved in biosynthesis of these compounds. About 343 million reads were generated from different tissues (leaf, flower and root) of C....

BACKGROUND Catharanthus roseus L (C. roseus) has been used to treat a wide assortment of diseases including diabetes. The objective of our study was to evaluate the antimicrobial and wound healing activity of the flower extract of Catharanthus in rats. METHODS Wound healing activity was determined in rats, after administration (100 mg kg-1 day-1) of the ethanol extract of C. roseus flower, us...