BACKGROUND Sperm dysfunction caused by reactive oxygen species (ROSs) is one of the major causes of infertility in men, which leads to, lipid peroxidation (LPO) and the formation of stable peroxidation products like Malondialdehyde (MDA) in seminal plasma. MDA is effective factor in reducing fertility. OBJECTIVES The aim of this study is to determine two biochemical markers of oxidative stres...

Reduced sperm quantity and motility are primary causes of infertility in men. Before researchers showed that, Nsun7 gene has roles in sperm motility of mouse, that creation defect in this gene is cause infertility. This gene in human located in chromosome 4, with 12 exons and a hot spot exon (exon7). Our aim is study of the mutations of the exon7 in the normospermic and asthenoteratospermic men...

Complimentary or natural antioxidant type of alternative medicine is developed worldwide to treat male infertility. The aim of this study is to the extraction of T. arjuna bark and activity against human sperm DNA damage in asthenoteratospermic smoker's subjects-an in vitro study. All preliminary and antioxidant assays (DPPH, H2O2, and total antioxidant, reducing power activity) were done. T. a...

reduced sperm quantity and motility are primary causes of infertility in men. before researchers showed that, nsun7 gene has roles in sperm motility of mouse, that creation defect in this gene is cause infertility. this gene in human located in chromosome 4, with 12 exons and a hot spot exon (exon7). our aim is study of the mutations of the exon7 in the normospermic and asthenoteratospermic men...

results seminal plasma tac level in normospermic men was significantly higher than asthenoteratospermic men (p < 0.001) and oligasthenoteratospermic men (p < 0.001) and had posetive correlation with sperm count, motility and morphology. in contrast mda levels in normospermic men were significantly lower than in asthenoteratospermic men (p = 0.049) and oligoasthenoteratospermic men (p = 0.001) a...

In most mammalian species aromatase is encoded by a single gene (Cyp19), which contains 18 exons, nine of them being translated. In man, the presence of a biologically active aromatase and oestrogen receptors (ERalpha and ERbeta) has been reported in Leydig cells, and also in immature germ cells and ejaculated spermatozoa. Concerning aromatase, the amount of transcript and enzymatic activity ar...

AIM To study the immune-modulating and anti-oxidant effects of beta-glucan, papaya, lactoferrin, and vitamins C and E on sperm characteristics of patients with asthenoteratozoospermia associated with leucocytosis. METHODS Fifty-one patients referred to our Sterility Center for semen analysis were selected. Sperm parameters were assessed before and after patient's treatment with beta-glucan, l...

OBJECTIVE To localize foci of single-stranded (ss) DNA in sperm nuclei of fertile and infertile men. DESIGN Prospective, observational study. SETTING University infertility clinic. PATIENT(S) Semen samples from 12 consecutive asthenoteratospermic men presenting for infertility evaluation and 5 consecutive fertile men presenting for vasectomy. INTERVENTION(S) Semen analysis, semen proces...

Background: Results of artificial insemination (AI) still does not exceed 20-25% because of different factors one of them is male factor infertility. Therefore, the global companies concern on the culture media that used for activation of semen samples of infertile men. However, till now, there are many semen samples did not response to these media leading to failure in AI. The objective of thi...