Materials and Methods: The stable state kinetic for comparison of inhibitory effect of artimisinin, dihydroartimisinin and cyclosporine A on calcineurin activation was used in this study. First, the best inhibitory concentration of artimisinin, dihydroartimisinin and cyclosporine A was calculated. Afterwards, the km and Vmax of them in the presence of substrate, paranitrophenylphosphate (PNPP) ...

objective: cutaneous leishmaniasis is an endemic infectious disease considered to be a crucial health problem in many countries, including iran. as such, there is a need for new medications with few side effects. in the present research we have studied the effect of artimisinin on  leishmania major (l. major) and cell death in vitro. methods: a specific number of promastigotes of l. major were ...

background and objective: artimisinin (an anti-malaria drug) is extracted from artemisia annua and its water soluble derivative is dihydroartimisinin. previous in vivo and in vitro studies showed that it has an inhibitory effect on t cells. it is also useful for immunosuppression of immune system. materials and methods: the stable state kinetic for comparison of inhibitory effect of artimisinin...

Background and Objective: Artimisinin (an anti-malaria drug) is extracted from Artemisia annua and its water soluble derivative is dihydroartimisinin. Previous in vivo and in vitro studies showed that it has an inhibitory effect on T cells. It is also useful for immunosuppression of immune system. Materials and Methods: The stable state kinetic for comparison of inhibitory effect of artimisinin...

Copyright: © 2014 Mohan K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract The burden of neonatal malaria was thought rare in the past because of presence of protective factors such as maternal...

Drug resistance in Plasmodium falciparum parasites is associated with the single nucleotide polymorphism (SNP) exo-E415G, which considered as a marker to reduce susceptibility artimisinin and leads treatment failure. This study aims establish procedure based on tetra-primer ARMS PCR technique detect SNP exo-E415G malaria patients who experienced failure artemisinin. DNA sample from P. 3D7 isola...

Studies were conducted on the effect of amino acids and growth regulators on the production of artemisinin, an antimalarial compound, in the callus of Artemisia absinthium. Callus was initiated on solid MS medium supplemented with BAP and NAA from leaf explant. For the production of artemisinin, the callus was proliferated on sterile filter paper bridge in MS medium supplemented with different ...

Hairy roots are genetically transformed roots and highly recommended sources for various secondary metabolites products. Artimisinin is one of them and frequently utilized as pharmaceutical drug for malaria impairment. Hairy roots are fragile tissue and very much sensitive in regarding to culture inside the bioreactor. Designing of bioreactor and optimising the acquired physical and chemical pa...

Cerebral malaria is a rapidly progressive potentially fatal complication of Plasmodium falciparum infection. It is characterized by unarousable and persistent coma along with symmetrical motor signs. Children, pregnant women and non-immune adults are more susceptible to have cerebral malaria. Several clinical, histopathological and laboratory studies have suggested that cytoadherence of parasit...